Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan-Induced Paw Inflammation in Rats

被引：19
作者：
Ortiz, Mario I. [1 ]
Carino-Cortes, Raquel [1 ]
Ponce-Monter, Hector A. [1 ]
Gonzalez-Garcia, Martha P. [1 ]
Castaneda-Hernandez, Gilberto [2 ]
Salinas-Caballero, Mireya [3 ]
机构：
[1] Univ Autonoma Estado Hidalgo, Inst Ciencias Salud, Area Acad Med, Pachuca, Hidalgo, Mexico
[2] Inst Politecn Nacl, Ctr Invest Estudios Avanzados, Dept Farmacol, Mexico City, DF, Mexico
[3] Lab Sanfer SA CV, Unidad Corporat Farmacovigilancia, Mexico City, DF, Mexico
来源：
DRUG DEVELOPMENT RESEARCH | 2017年 / 78卷 / 07期
关键词：
non-steroidal anti-inflammatory drugs; gastric damage; Matricaria chamomilla; inflammation; synergism; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; NEUTROPHIL MIGRATION; KAPPA-B; MECHANISM; PAIN; (-)-ALPHA-BISABOLOL; GASTROPROTECTION; CYCLOOXYGENASE; MACROPHAGES; INHIBITORS;
D O I：
10.1002/ddr.21401
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The coadministration of non-steroidal anti-inflammatory drugs (NSAIDs) with medicinal plant extracts may increase anti-inflammatory activity, thus permitting the use of lower NSAID doses and limiting the side effects. The aim of this study was to explore the interactions between an ethanolic extract of M. chamomilla extract (MCE) with two NSAIDs, diclofenac and indomethacin on carrageenan-induced paw inflammation and gastric injury in rats. Diclofenac, indomethacin and MCE, or combinations with MCE produced an anti-inflammatory effect. Effective dose (ED) values were estimated for the individual drugs, and isobolograms were constructed. The final experimental ED values were 483.7 mg/kg for diclofenac+MCE combination, and 212.6 mg/kg for indomethacin+MCE. These values were lower (p<0.05) than the theoretical ED values (1186.9 mg/kg for diclofenac+MCE combination, and 1183.8 mg/kg for indomethacin+MCE). These data suggest that the interactions between NSAIDs and MCE that mediate the anti-inflammatory effects at the systemic level are synergistic and may have therapeutic advantages for the clinical treatment of inflammatory processes. Drug Dev Res 78 : 360-367, 2017. (c) 2017 Wiley Periodicals, Inc.
引用
收藏
页码：360 / 367
页数：8
相关论文
共 30 条
[1]   Vascular permeability, neutrophil migration and edematogenic effects induced by the latex of Cryptostegia grandiflora [J].
Albuquerque, Tatiana M. ;
Alencar, Nylane M. N. ;
Figueiredo, Jozi G. ;
Figueiredo, Ingrid S. T. ;
Teixeira, Cinthia M. ;
Bitencourt, Flavio S. ;
Secco, Daniela D. ;
Araujo, Eliane S. ;
Ana Maria Leao, C. A. ;
Ramos, Marcio V. .
TOXICON, 2009, 53 (01) :15-23
[2]   Discovery and resupply of pharmacologically active plant-derived natural products: A review [J].
Atanasov, Atanas G. ;
Waltenberger, Birgit ;
Pferschy-Wenzig, Eva-Maria ;
Linder, Thomas ;
Wawrosch, Christoph ;
Uhrin, Pavel ;
Temml, Veronika ;
Wang, Limei ;
Schwaiger, Stefan ;
Heiss, Elke H. ;
Rollinger, Judith M. ;
Schuster, Daniela ;
Breuss, Johannes M. ;
Bochkov, Valery ;
Mihovilovic, Marko D. ;
Kopp, Brigitte ;
Bauer, Rudolf ;
Dirsch, Verena M. ;
Stuppner, Hermann .
BIOTECHNOLOGY ADVANCES, 2015, 33 (08) :1582-1614
[3]  
Baylac S., 2003, International Journal of Aromatherapy, V13, P138, DOI 10.1016/S0962-4562(03)00083-3
[4]   Bisabolol-Induced Gastroprotection Against Acute Gastric Lesions: Role of Prostaglandins, Nitric Oxide, and KATP+ Channels [J].
Bezerra, S. B. ;
Leal, L. K. A. M. ;
Pinto, N. A. N. ;
Campos, A. R. .
JOURNAL OF MEDICINAL FOOD, 2009, 12 (06) :1403-1406
[5]   Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein [J].
Cong, Xiao-Dong ;
Wu, You ;
Dai, De-Zai ;
Ding, Ming-Jian ;
Zhang, Yun ;
Dai, Yin .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2012, 64 (08) :1138-1145
[6]   Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism [J].
El-Shitany, Nagla A. ;
El-Bastawissy, Eman A. ;
El-desoky, Karema .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2014, 19 (02) :290-299
[7]   Diclofenac: an update on its mechanism of action and safety profile [J].
Gan, Tong J. .
CURRENT MEDICAL RESEARCH AND OPINION, 2010, 26 (07) :1715-1731
[8]   Inhibitory effects of (-)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages [J].
Kim, Seungbeom ;
Jung, Eunsun ;
Kim, Jang-Hyun ;
Park, Young-Ho ;
Lee, Jongsung ;
Park, Deokhoon .
FOOD AND CHEMICAL TOXICOLOGY, 2011, 49 (10) :2580-2585
[9]   Management of NSAID-Induced Gastrointestinal Toxicity Focus on Proton Pump Inhibitors [J].
Lazzaroni, Marco ;
Porro, Gabriele Bianchi .
DRUGS, 2009, 69 (01) :51-69
[10]   Influence of verapamil and diclofenac on leukocyte migration in rats [J].
Martinez, LL ;
de Oliveira, A ;
Fortes, ZB .
HYPERTENSION, 1999, 34 (04) :997-1001
123