Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective

被引：39

作者：

ten Brinke, Anja ^{[1
,2
]}

Martinez-Llordella, Marc ^{[3
]}

Cools, Nathalie ^{[4
]}

Hilkens, Catharien M. U. ^{[5
]}

van Ham, S. Marieke ^{[1
,2
,6
]}

Sawitzki, Birgit ^{[7
]}

Geissler, Edward K. ^{[8
]}

Lombardi, Giovanna ^{[9
]}

Trzonkowski, Piotr ^{[10
]}

Martinez-Caceres, Eva ^{[11
,12
]}

机构：

[1] Sanquin Res, Dept Immunopathol, Amsterdam, Netherlands

[2] Univ Amsterdam, Amsterdam UMC, Landsteiner Lab, Amsterdam, Netherlands

[3] Kings Coll London, Dept Inflammat Biol, MRC Ctr Transplantat, Sch Immunol & Microbial Sci,Inst Liver Studies, London, England

[4] Univ Antwerp, Lab Expt Hematol, Fac Med & Hlth Sci, Vaccine & Infect Dis Inst Vaxinfectio, Antwerp, Belgium

[5] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England

[6] Univ Amsterdam, Swammerdam Inst Life Sci, Amsterdam, Netherlands

[7] Charite Univ Med Berlin, Berlin Inst Hlth, Inst Med Immunol, Humboldt Univ Berlin, Berlin, Germany

[8] Univ Regensburg, Univ Hosp Regensburg, Sect Expt Surg, Dept Surg, Regensburg, Germany

[9] Kings Coll London, Guys Hosp, Div Transplantat Immunol & Mucosal Biol, MRC Ctr Transplantat, London, England

[10] Med Univ Gdansk, Dept Clin Immunol & Transplantol, Gdansk, Poland

[11] Germans Trias & Pujol Univ Hosp, Div Immunol, LCMN, IGTP, Badalona, Spain

[12] Univ Autonoma Barcelona, Dept Cellular Biol Physiol & Immunol, Cerdanyola Del Valles, Spain

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

基金：

欧盟地平线“2020”;

关键词：

tolerance; dendritic cells; regulatory T cells; autoimmunity; transplantation; cell therapy; clinic; immunomonitoring; REGULATORY T-CELLS; TOLEROGENIC DENDRITIC CELLS; MULTIPLE-SCLEROSIS; ADOPTIVE TRANSFER; FLOW-CYTOMETRY; AUTOIMMUNE-DISEASES; ALLOGRAFT SURVIVAL; IN-VIVO; TRANSPLANTATION; CD4(+);

D O I：

10.3389/fimmu.2019.00181

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.

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页数：20

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