Genetic polymorphisms in glycolytic pathway are associated with the prognosis of patients with early stage non-small cell lung cancer

被引：25

作者：

Lee, Shin Yup ^{[1
,2
]}

Jin, Cheng Cheng ^{[3
,4
]}

Choi, Jin Eun ^{[3
,5
]}

Hong, Mi Jeong ^{[3
,4
]}

Jung, Deuk Kju ^{[3
,4
]}

Do, Sook Kyung ^{[3
,4
]}

Baek, Sun Ah ^{[3
]}

Kang, Hyo Jung ^{[3
]}

Kang, Hyo-Gyoung ^{[3
,5
]}

Choi, Sun Ha ^{[2
]}

Lee, Won Kee ^{[6
]}

Seok, Yangki ^{[1
,7
]}

Lee, Eung Bae ^{[1
,7
]}

Jeong, Ji Yun ^{[8
]}

Shin, Kyung Min ^{[9
]}

Cho, Sukki ^{[10
]}

Yoo, Seung Soo ^{[1
,2
]}

Lee, Jaehee ^{[2
]}

Cha, Seung Ick ^{[2
]}

Kim, Chang Ho ^{[2
]}

Lee, You Mie ^{[11
]}

Lee, In-Kyu ^{[2
]}

Jheon, Sanghoon ^{[10
]}

Park, Jae Yong ^{[1
,2
,3
,4
,5
]}

机构：

[1] Kyungpook Natl Univ, Lung Canc Ctr, Med Ctr, Daegu 41404, South Korea

[2] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea

[3] Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea

[4] Kyungpook Natl Univ, Plus KNU Biomed Convergence Program BK21, Dept Biomed Sci, Daegu 41944, South Korea

[5] Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu 41944, South Korea

[6] Kyungpook Natl Univ, Ctr Biostat, Sch Med, Daegu 41944, South Korea

[7] Kyungpook Natl Univ, Dept Thorac Surg, Sch Med, Daegu 41944, South Korea

[8] Kyungpook Natl Univ, Dept Pathol, Sch Med, Daegu 41944, South Korea

[9] Kyungpook Natl Univ, Dept Radiol, Sch Med, Daegu 41944, South Korea

[10] Seoul Natl Univ, Sch Med, Dept Thorac & Cardiovasc Surg, Seoul 13620, South Korea

[11] Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

PYRUVATE-DEHYDROGENASE KINASE; THERAPEUTIC TARGET; GLUCOSE-METABOLISM; ENERGY-METABOLISM; MITOCHONDRIA; APOPTOSIS; ALPHA; ENO1; P53;

D O I：

10.1038/srep35603

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study was conducted to investigate whether polymorphisms of genes involved in glycolysis are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Forty-four single nucleotide polymorphisms (SNPs) of 17 genes in glycolytic pathway were investigated in a total of 782 patients with NSCLC who underwent curative surgical resection. The association of the SNPs with overall survival (OS) and disease free survival (DFS) were analyzed. Among the 44 SNPs investigated, four SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, PFKP rs1132173C > T, PDK2 rs3785921G > A) were significantly associated with survival outcomes in multivariate analyses. When stratified by tumor histology, three SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, and PDK2 rs3785921G > A) were significantly associated with OS and/or DFS only in squamous cell carcinoma, whereas PFKP rs1132173C > T exhibited a significant association with survival outcomes only in adenocarcinoma. When the four SNPs were combined, OS and DFS decreased as the number of bad genotypes increased (Ptrend = 8 x 10(-4) and 3 x 10(-5), respectively). Promoter assays showed that ENO1 rs2274971G allele had significantly higher promoter activity compared to the rs2274971A allele. The four SNPs, especially ENO1 rs2274971A > G, may be useful for the prediction of prognosis in patients with surgically resected NSCLC.

引用

页数：10

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