Asymptotic Stability Analysis of Genetic Regulatory Networks with Time-varying Delay

被引:8
作者
Li, Hongjie [1 ]
Yang, Xiaochun [1 ]
机构
[1] Jiaxing Univ, Coll Math & Informat Engn, Jiaxing 314001, Zhejiang, Peoples R China
来源
2010 CHINESE CONTROL AND DECISION CONFERENCE, VOLS 1-5 | 2010年
关键词
Genetic regulatory network; Asymptotic stability; Time-varying delays; Linear matrix inequality(LMI); H-INFINITY CONTROL; ROBUST STABILITY; NEURAL-NETWORKS; SYSTEMS; UNCERTAINTY; DISCRETE; NOISE;
D O I
10.1109/CCDC.2010.5498985
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
This paper presents a analysis approach to asymptotic stability of the genetic regulatory networks with interval time-varying delays, the delays play an important role in dynamics of genetic networks and cannot be ignored in the modeling of genetic regulation due to slow biochemical reactions. The free weighting matrices are employed to deal with cross product items, and the convexity of the matrix function is fully utilized in our proof to obtain less conservativeness, by utilizing some techniques, both the upper and lower bounds of the delays are brought into final stability conditions. Based on the Lyapunov stability theory and linear matrix inequality, sufficient conditions are given to ensure the asymptotic stability of the genetic regulatory networks, the obtained conditions are derived in terms of LMIs which are easy to be verified via the LMI toolbox. Illustrative examples are provided to show the effectiveness of our proposed method.
引用
收藏
页码:566 / 571
页数:6
相关论文
共 20 条
[1]   Gene network shaping of inherent noise spectra [J].
Austin, DW ;
Allen, MS ;
McCollum, JM ;
Dar, RD ;
Wilgus, JR ;
Sayler, GS ;
Samatova, NF ;
Cox, CD ;
Simpson, ML .
NATURE, 2006, 439 (7076) :608-611
[2]   Engineering stability in gene networks by autoregulation [J].
Becskei, A ;
Serrano, L .
NATURE, 2000, 405 (6786) :590-593
[3]   Modeling transcriptional regulatory networks [J].
Bolouri, H ;
Davidson, EH .
BIOESSAYS, 2002, 24 (12) :1118-1129
[4]   Stability of genetic regulatory networks with time delay [J].
Chen, LN ;
Aihara, K .
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS, 2002, 49 (05) :602-608
[5]   Modeling and simulation of genetic regulatory systems: A literature review [J].
De Jong, H .
JOURNAL OF COMPUTATIONAL BIOLOGY, 2002, 9 (01) :67-103
[6]   A synthetic oscillatory network of transcriptional regulators [J].
Elowitz, MB ;
Leibler, S .
NATURE, 2000, 403 (6767) :335-338
[7]   Construction of a genetic toggle switch in Escherichia coli [J].
Gardner, TS ;
Cantor, CR ;
Collins, JJ .
NATURE, 2000, 403 (6767) :339-342
[8]   A coherent feed-forward loop with a SUM input function prolongs flagella expression in Escherichia coli [J].
Kalir, Shiraz ;
Mangan, Shmoolik ;
Alon, Uri .
MOLECULAR SYSTEMS BIOLOGY, 2005, 1 (1) :2005.0006
[9]   Stability of genetic networks with SUM regulatory logic: Lur'e system and LMI approach [J].
Li, Chunguang ;
Chen, Luonan ;
Aihara, Kazuyuki .
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS, 2006, 53 (11) :2451-2458
[10]   Asymptotic and robust stability of genetic regulatory networks with time-varying delays [J].
Ren, Fengi ;
Cao, Jinde .
NEUROCOMPUTING, 2008, 71 (4-6) :834-842