Human breast lesions: Characterization with contrast-enhanced in vivo proton MR spectroscopy - Initial results

被引:143
作者
Yeung, DKW
Cheung, HS
Tse, GMK
机构
[1] Prince Wales Hosp, Dept Clin Oncol, Med Phys Div, Shatin, Hong Kong, Peoples R China
[2] Prince Wales Hosp, Dept Diagnost Radiol & Organ Imaging, Shatin, Hong Kong, Peoples R China
[3] Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China
关键词
breast neoplasms; diagnosis; magnetic resonance (MR); contrast enhancement; spectroscopy; metabolism;
D O I
10.1148/radiology.220.1.r01jl0240
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PURPOSE: To assess the clinical usefulness of localized proton (hydrogen 1) magnetic resonance (MR) spectroscopy in the characterization of contrast material-enhanced breast lesions on the basis: of choline: detection. MATERIALS AND METHODS: Examinations were performed at 1.5 T with use of a standard breast coil. Contrast-enhanced MR imaging was performed in 30 consecutive patients (mean age, 50 years; age range, 20-80 years) who had nonspecific lesions (>1.5 cm in diameter) on sonograms or mammograms. Single-voxel H-1 MR spectroscopy was performed in the enhancing lesions by using a point-resolved spectroscopic sequence with echo times of 38, 135, and 270 msec; MR spectroscopic and histopathologic findings were determined in blinded fashion and compared. RESULTS: Twenty-four patients had carcinoma of the breast (tumor size, 2.0-11.2 cm; mean, 4.7 cm), and six had benign lesions (lesion size, 1.8-3.8 cm; mean, 2.7 cm). Choline was detected in 22 patients with carcinoma. Choline was not detected in five patients with benign lesions and in two patients with carcinoma. The preliminary results indicate that this technique had a sensitivity of 92%, specificity of 83%, and accuracy of 90%. CONCLUSION: Choline can be reliably detected in less than 45 minutes in large contrast-enhanced breast lesions by using a multiecho point-resolved spectroscopic protocol. The presence of water-soluble choline metabolites obtainable with H-1 MR spectroscopy could complement MR imaging findings to improve specificity and to reduce the number of unnecessary biopsies.
引用
收藏
页码:40 / 46
页数:7
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