Recyclable and reusable Pd(OAc)2/DABCO/PEG-400 system for Suzuki-Miyaura cross-coupling reaction

被引：202

作者：

Li, JH ^{[1
]}

Liu, WJ ^{[1
]}

Xie, YX ^{[1
]}

机构：

[1] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 14期

关键词：

D O I：

10.1021/jo050353m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stable and efficient Pd(OAc)(2)/DABCO (triethylenediamine) catalytic system for Suzuki-Miyaura cross-coupling reaction has been developed. In the presence of Pd(OAc)2 and DABCO, coupling of aryl halides with arylboronic acids was carried out smoothly to afford good to excellent yields and high turnover numbers (TONS) (the maximal TONS were up to 960 000 for the reaction of 1-iodo4-nitrobenzene with phenylboronic acid) using PEG-400 as the solvent. Moreover, the Pd(OAc)(2)/ DABCO/PEG-400 system could be recycled and reused five times without any loss of catalytic activity for aryl iodides and bromides.

引用

页码：5409 / 5412

页数：4

共 73 条

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