A simple quantitative chiral analysis of amino acid esters by fluorine-19 nuclear magnetic resonance using the modified James-Bull method

被引：9
作者：
Hamaguchi, Naoto [1 ]
Okuno, Yuta [1 ]
Oe, Yohei [1 ]
Ohta, Tetsuo [1 ]
机构：
[1] Doshisha Univ, Fac Life & Med Sci, Dept Biomed Informat, 1-3 Miyakodani, Kyotanabe, Kyoto 6100394, Japan
来源：
CHIRALITY | 2019年 / 31卷 / 01期
关键词：
F-19; NMR; amino acids; James-bull assembly; quantification; ENANTIOMERIC PURITY; SIMPLE PROTOCOL; NMR ANALYSIS;
D O I：
10.1002/chir.23028
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A simple chiral analysis of amino acid esters by fluorine-19 nuclear magnetic resonance (F-19 NMR) through the modified James-Bull method is described. Thus, amino acid ester acid salt was treated with 5-fluoro-2-formylphenylboronic acid and (S)-BINOL in the presence of triethylamine (TEA) and MS4A for 10 minutes. The reaction mixture was analysed by F-19 NMR directly to afford good quantifications.
引用
收藏
页码：34 / 40
页数：7
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