Cell entry by SARS-CoV-2

被引：128

作者：

Peng, Ruchao ^{[1
,5
]}

Wu, Lian-Ao ^{[2
]}

Wang, Qingling ^{[3
]}

Qi, Jianxun ^{[1
,2
,4
]}

Gao, George Fu ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[2] Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230039, Peoples R China

[3] Northwest Univ, Coll Food Sci & Technol, Shanxi Nat Carbohydrate Resource Engn Res Ctr, Xian 710069, Peoples R China

[4] Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China

[5] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2021年 / 46卷 / 10期

关键词：

SPIKE PROTEIN; STRUCTURAL BASIS; CORONAVIRUS; BINDING; VIRUS; ACE2; TRANSMISSION; INFECTION; IDENTIFICATION; GLYCOPROTEIN;

D O I：

10.1016/j.tibs.2021.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Severe acute respiratory syndrome virus 2 (SARS-CoV-2) invades host cells by interacting with receptors/coreceptors, as well as with other cofactors, via its spike (S) protein that further mediates fusion between viral and cellular membranes. The host membrane protein, angiotensin-converting enzyme 2 (ACE2), is the major receptor for SARS-CoV-2 and is a crucial determinant for cross-species transmission. In addition, some auxiliary receptors and cofactors are also involved that expand the host/tissue tropism of SARS-CoV-2. After receptor engagement, specific proteases are required that cleave the S protein and trigger its fusogenic activity. Here we discuss the recent advances in understanding the molecular events during SARS-CoV-2 entry which will contribute to developing vaccines and therapeutics.

引用

页码：848 / 860

页数：13

共 112 条

[1] SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis [J].

Bayati, Armin ;

Kumar, Rahul ;

Francis, Vincent ;

McPherson, Peter S. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 296

[2] Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein [J].

Belouzard, Sandrine ;

Millet, Jean K. ;

Licitra, Beth N. ;

Whittaker, Gary R. .

VIRUSES-BASEL, 2012, 4 (06) :1011-1033

[3] Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion [J].

Benton, Donald J. ;

Wrobel, Antoni G. ;

Xu, Pengqi ;

Roustan, Chloe ;

Martin, Stephen R. ;

Rosenthal, Peter B. ;

Skehel, John J. ;

Gamblin, Steven J. .

NATURE, 2020, 588 (7837) :327-330

[4] TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells [J].

Bestle, Dorothea ;

Heindl, Miriam Ruth ;

Limburg, Hannah ;

Thuy Van Lam Van ;

Pilgram, Oliver ;

Moulton, Hong ;

Stein, David A. ;

Hardes, Kornelia ;

Eickmann, Markus ;

Dolnik, Olga ;

Rohde, Cornelius ;

Klenk, Hans-Dieter ;

Garten, Wolfgang ;

Steinmetzer, Torsten ;

Boettcher-Friebertshaeuser, Eva .

LIFE SCIENCE ALLIANCE, 2020, 3 (09)

[5]

Cai YF, 2020, SCIENCE, V369, P1586, DOI [10.1126/science.abd4251, 10.1101/2020.05.16.099317]

[6] Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity [J].

Cantuti-Castelvetri, Ludovico ;

Ojha, Ravi ;

Pedro, Liliana D. ;

Djannatian, Minou ;

Franz, Jonas ;

Kuivanen, Suvi ;

van der Meer, Franziska ;

Kallio, Katri ;

Kaya, Tugberk ;

Anastasina, Maria ;

Smura, Teemu ;

Levanov, Lev ;

Szirovicza, Leonora ;

Tobi, Allan ;

Kallio-Kokko, Hannimari ;

Osterlund, Pamela ;

Joensuu, Merja ;

Meunier, Frederic A. ;

Butcher, Sarah J. ;

Winkler, Martin Sebastian ;

Mollenhauer, Brit ;

Helenius, Ari ;

Gokce, Ozgun ;

Teesalu, Tambet ;

Hepojoki, Jussi ;

Vapalahti, Olli ;

Stadelmann, Christine ;

Balistreri, Giuseppe ;

Simons, Mikael .

SCIENCE, 2020, 370 (6518) :856-+

[7] Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells [J].

Cao, Yunlong ;

Su, Bin ;

Guo, Xianghua ;

Sun, Wenjie ;

Deng, Yongqiang ;

Bao, Linlin ;

Zhu, Qinyu ;

Zhang, Xu ;

Zheng, Yinghui ;

Geng, Chenyang ;

Chai, Xiaoran ;

He, Runsheng ;

Li, Xiaofeng ;

Lv, Qi ;

Zhu, Hua ;

Deng, Wei ;

Xu, Yanfeng ;

Wang, Yanjun ;

Qiao, Luxin ;

Tan, Yafang ;

Song, Liyang ;

Wang, Guopeng ;

Du, Xiaoxia ;

Gao, Ning ;

Liu, Jiangning ;

Xiao, Junyu ;

Su, Xiao-dong ;

Du, Zongmin ;

Feng, Yingmei ;

Qin, Chuan ;

Qin, Chengfeng ;

Jin, Ronghua ;

Xie, X. Sunney .

CELL, 2020, 182 (01) :73-+

[8] Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein [J].

Casalino, Lorenzo ;

Gaieb, Zied ;

Goldsmith, Jory A. ;

Hjorth, Christy K. ;

Dommer, Abigail C. ;

Harbison, Aoife M. ;

Fogarty, Carl A. ;

Barros, Emilia P. ;

Taylor, Bryn C. ;

McLellan, Jason S. ;

Fadda, Elisa ;

Amaro, Rommie E. .

ACS CENTRAL SCIENCE, 2020, 6 (10) :1722-1734

[9] Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus [J].

Chen, ZN ;

Mi, L ;

Xu, J ;

Yu, JY ;

Wang, XH ;

Jiang, JL ;

Xing, JL ;

Shang, P ;

Qian, AR ;

Li, Y ;

Shaw, PX ;

Wang, JW ;

Duan, SM ;

Ding, J ;

Fan, CM ;

Zhang, Y ;

Yang, Y ;

Yu, XL ;

Feng, Q ;

Li, BH ;

Yao, XY ;

Zhang, Z ;

Li, L ;

Xue, XP ;

Zhu, P .

JOURNAL OF INFECTIOUS DISEASES, 2005, 191 (05) :755-760

[10] Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects [J].

Cheng, Ya-Wen ;

Chao, Tai-Ling ;

Li, Chiao-Ling ;

Chiu, Mu-Fan ;

Kao, Han-Chieh ;

Wang, Sheng-Han ;

Pang, Yu-Hao ;

Lin, Chih-Hui ;

Tsai, Ya-Min ;

Lee, Wen-Hau ;

Tao, Mi-Hua ;

Ho, Tung-Ching ;

Wu, Ping-Yi ;

Jang, Li-Ting ;

Chen, Pei-Jer ;

Chang, Sui-Yuan ;

Yeh, Shiou-Hwei .

CELL REPORTS, 2020, 33 (02)

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