Decision making: An analogue implementation of a drift-diffusion computation in the Drosophila mushroom body

被引：1

作者：

Buerkle, Nathan ^{[1
]}

Jeanne, James M. ^{[1
]}

机构：

[1] Yale Univ, Dept Neurosci, 333 Cedar St, New Haven, CT 06510 USA

来源：

CURRENT BIOLOGY | 2021年 / 31卷 / 22期

基金：

英国惠康基金;

关键词：

NEURONS; MODELS;

D O I：

10.1016/j.cub.2021.09.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new study combines electrophysiology, optogenetics, and behavior to investigate a decision-making circuit in the fly brain, revealing all the major features predicted by drift-diffusion models. Strikingly, much of this computation takes place subthreshold, independent of action potentials.

引用

页码：R1479 / +

页数：4

共 20 条

[1] Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila [J].

Aso, Yoshinori ;

Sitaraman, Divya ;

Ichinose, Toshiharu ;

Kaun, Karla R. ;

Vogt, Katrin ;

Belliart-Guerin, Ghislain ;

Placais, Pierre-Yves ;

Robie, Alice A. ;

Yamagata, Nobuhiro ;

Schnaitmann, Christopher ;

Rowell, William J. ;

Johnston, Rebecca M. ;

Ngo, Teri-T B. ;

Chen, Nan ;

Korff, Wyatt ;

Nitabach, Michael N. ;

Heberlein, Ulrike ;

Preat, Thomas ;

Branson, Kristin M. ;

Tanimoto, Hiromu ;

Rubin, Gerald M. .

ELIFE, 2014, 3 :e04580

[2] The neuronal architecture of the mushroom body provides a logic for associative learning [J].

Aso, Yoshinori ;

Hattori, Daisuke ;

Yu, Yang ;

Johnston, Rebecca M. ;

Iyer, Nirmala A. ;

Ngo, Teri-T B. ;

Dionne, Heather ;

Abbott, L. F. ;

Axel, Richard ;

Tanimoto, Hiromu ;

Rubin, Gerald M. .

ELIFE, 2014, 3 :e04577

[3] Neural circuits for evidence accumulation and decision making in larval zebrafish [J].

Bahl, Armin ;

Engert, Florian .

NATURE NEUROSCIENCE, 2020, 23 (01) :94-+

[4] The physics of optimal decision making: A formal analysis of models of performance in two-alternative forced-choice tasks [J].

Bogacz, Rafal ;

Brown, Eric ;

Moehlis, Jeff ;

Holmes, Philip ;

Cohen, Jonathan D. .

PSYCHOLOGICAL REVIEW, 2006, 113 (04) :700-765

[5] Random convergence of olfactory inputs in the Drosophila mushroom body [J].

Caron, Sophie J. C. ;

Ruta, Vanessa ;

Abbott, L. F. ;

Axel, Richard .

NATURE, 2013, 497 (7447) :113-+

[6] Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila [J].

Cohn, Raphael ;

Morantte, Ianessa ;

Ruta, Vanessa .

CELL, 2015, 163 (07) :1742-1755

[7] FoxP influences the speed and accuracy of a perceptual decision in Drosophila [J].

DasGupta, Shamik ;

Ferreira, Clara Howcroft ;

Miesenboeck, Gero .

SCIENCE, 2014, 344 (6186) :901-904

[8] The neural basis of decision making [J].

Gold, Joshua I. ;

Shadlen, Michael N. .

ANNUAL REVIEW OF NEUROSCIENCE, 2007, 30 :535-574

[9] GRADED SYNAPTIC TRANSMISSION BETWEEN SPIKING NEURONS [J].

GRAUBARD, K ;

RAPER, JA ;

HARTLINE, DK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (06) :3733-3735

[10] Dendritic Integration of Sensory Evidence in Perceptual Decision-Making [J].

Groschner, Lukas N. ;

Hak, Laura Chan Wah ;

Bogacz, Rafal ;

DasGupta, Shamik ;

Miesenbock, Gero .

CELL, 2018, 173 (04) :894-+

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