Carbenoxolone, a new inducer of heat shock protein 70

被引：29
|
作者：
Nagayama, S
Jono, H
Suzaki, H
Sakai, K
Tsuruya, E
Yamatsu, I
Isohama, Y
Miyata, T
Kai, H
机构：
[1] Kumamoto Univ, Fac Pharmaceut Sci, Dept Pharmacol Sci, Kumamoto 8620973, Japan
[2] Serendip Inst, Tokyo 1160002, Japan
来源：
LIFE SCIENCES | 2001年 / 69卷 / 24期
关键词：
carbenoxolone; heat shock protein 70; heat shock factor 1;
D O I：
10.1016/S0024-3205(01)01362-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Heat shock protein 70 (Hsp70) is capable of protecting cells, tissues, organs, and animals from a subsequent, normally lethal heating, as well as from numerous disease states. Therefore, it would be of great therapeutic benefit to discover compounds that are clinically safe yet able to induce Hsp70 in patients. Carbenoxolone, an antiulcer drug, protects gastric mucosal cells against irritants in vivo and in vitro. We assessed here whether carbenoxolone induces Hsp70 expression in human cell lines. We found that carbenoxolone increased the expression of Hsp70 protein and mRNA, and Hsp70 promoter activity. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：2867 / 2873
页数：7
相关论文
共 50 条
  • [21] Leucinostatin acts as a co-inducer for heat shock protein 70 in cultured canine retinal pigment epithelial cells
    Qingkang Lyu
    Irene S. Ludwig
    Peter J. S. Kooten
    Alice J. A. M. Sijts
    Victor P. M. G. Rutten
    Willem van Eden
    Femke Broere
    Cell Stress and Chaperones, 2020, 25 : 235 - 243
  • [22] Leucinostatin acts as a co-inducer for heat shock protein 70 in cultured canine retinal pigment epithelial cells
    Lyu, Qingkang
    Ludwig, Irene S.
    Kooten, Peter J. S.
    Sijts, Alice J. A. M.
    Rutten, Victor P. M. G.
    van Eden, Willem
    Broere, Femke
    CELL STRESS & CHAPERONES, 2020, 25 (02): : 235 - 243
  • [23] Heat shock protein 70 and anti-heat shock protein 70 antibodies in nasal secretions of patients with chronic rhinosinusitis
    Tsybikov, Namjil N.
    Egorova, Elena V.
    Kuznik, Boris I.
    Fefelova, Elena V.
    Magen, Eli
    ALLERGY & RHINOLOGY, 2016, 7 (01): : E14 - E20
  • [24] Inhibition of Heat Shock Induction of Heat Shock Protein 70 and Enhancement of Heat Shock Protein 27 Phosphorylation by Quercetin Derivatives
    Wang, Rongsheng E.
    Kao, Jeffrey L. -F.
    Hilliard, Carolyn A.
    Pandita, Raj K.
    Roti, Joseph L. Roti
    Hunt, Clayton R.
    Taylor, John-Stephen
    JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (07) : 1912 - 1921
  • [25] Mitochondrial Heat Shock Protein 70: New Target for Optic Neuritis Therapy
    Adamus, Grazyna
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (08) : 5227 - 5227
  • [26] Response of circulating heat shock protein 70 and anti-heat shock protein 70 antibodies to catheter ablation of atrial fibrillation
    Jelena Kornej
    Claudia Reinhardt
    Jedrzej Kosiuk
    Arash Arya
    Gerhard Hindricks
    Volker Adams
    Daniela Husser
    Andreas Bollmann
    Journal of Translational Medicine, 11
  • [27] Response of circulating heat shock protein 70 and anti-heat shock protein 70 antibodies to catheter ablation of atrial fibrillation
    Kornej, Jelena
    Reinhardt, Claudia
    Kosiuk, Jedrzej
    Arya, Arash
    Hindricks, Gerhard
    Adams, Volker
    Husser, Daniela
    Bollmann, Andreas
    JOURNAL OF TRANSLATIONAL MEDICINE, 2013, 11
  • [28] cDNA of canine heat shock protein 70 (HSP70)
    Kano, R
    Abe, K
    Hasegawa, A
    VETERINARY RESEARCH COMMUNICATIONS, 2004, 28 (05) : 395 - 405
  • [29] Transfection of Heat Shock Protein 70 kDa (HSP70)
    Maxime Gestin
    Luca Falato
    Michela Ciccarelli
    Carmine Pasquale Cerrato
    Claes Andréasson
    Ülo Langel
    International Journal of Peptide Research and Therapeutics, 28
  • [30] cDNA of Canine Heat Shock Protein 70 (HSP70)
    R. Kano
    K. Abe
    A. Hasegawa
    Veterinary Research Communications, 2004, 28 : 395 - 405
12345