Autoimmune Polyendocrine Syndrome-3 in a Patient With Late-onset Multiple Sclerosis

被引：2

作者：

Yokote, Hiroaki ^{[1
]}

Nagasawa, Miki ^{[2
]}

Ichijo, Masahiko ^{[1
]}

Amino, Takeshi ^{[1
]}

Fujigasaki, Hiroto ^{[1
]}

机构：

[1] Musashino Red Cross Hosp, Dept Neurol, Musashino, Tokyo 1808610, Japan

[2] Musashino Red Cross Hosp, Dept Endocrinol, Musashino, Tokyo 1808610, Japan

来源：

NEUROLOGIST | 2012年 / 18卷 / 02期

关键词：

multiple sclerosis; autoimmune endocrine syndrome; late onset; HLA-DR4; type 1 diabetes mellitus; ALLELES; SUSCEPTIBILITY;

D O I：

10.1097/NRL.0b013e318248ea2a

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present here the rare case of a 73-year-old patient with very late-onset multiple sclerosis who developed autoimmune polyendocrine syndrome (APS)-3. Despite only a few reports describing the association between multiple sclerosis and APS, both of these diseases have been shown to be associated with HLA-DR4. Intriguingly, the HLA genotype profile of this patient included HLA-DR4 which, fine mapped to the DRB1*0405-DQA1*0303-DQB1*0401 extended haplotype, reported to be a susceptibility haplotype for APS-3 in Japan. This unique genetic background might explain the clinical picture of this patient.

引用

页码：83 / 84

页数：2

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