Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells

被引：28
作者：
Lee, Gap Ryol [1 ]
机构：
[1] Sogang Univ, Dept Life Sci, 35 Baekbeom Ro, Seoul 04107, South Korea
来源：
MEDIATORS OF INFLAMMATION | 2017年 / 2017卷
基金：
新加坡国家研究基金会;
关键词：
PROGNOSTIC VALUE; TRYPTOPHAN CATABOLISM; METABOLIC-REGULATION; ANTITUMOR IMMUNITY; THYMIC DEVELOPMENT; PD-1; BLOCKADE; LUNG-CANCER; TGF-BETA; LYMPHOCYTES; RECEPTOR;
D O I：
10.1155/2017/5458178
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Regulatory T (Treg) cells maintain immune homeostasis by suppressing excessive immune responses. Treg cells induce tolerance against self- and foreign antigens, thus preventing autoimmunity, allergy, graft rejection, and fetus rejection during pregnancy. However, Treg cells also infiltrate into tumors and inhibit antitumor immune responses, thus inhibiting anticancer therapy. Depleting whole Treg cell populations in the body to enhance anticancer treatments will produce deleterious autoimmune diseases. Therefore, understanding the precise nature of tumor-infiltrating Treg cells is essential for effectively targeting Treg cells in tumors. This review summarizes recent results relating to Treg cells in the tumor microenvironment, with particular emphasis on their accumulation, phenotypic, and functional properties, and targeting to enhance the efficacy of anticancer treatment.
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页数：9
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