Bone metastases and skeletal-related events: incidence and prognosis according to histological subtype of lung cancer

被引：16
作者：
Silva, Gustavo T. [1 ]
Silva, Larissy M. [2 ]
Bergmann, Anke [2 ]
Thuler, Luiz C. S. [2 ,3 ]
机构：
[1] Natl Canc Inst, Canc Hosp 1, Rio De Janeiro, Brazil
[2] Natl Canc Inst, Res Ctr, Rio De Janeiro, Brazil
[3] Fed Univ State Rio de Janeiro, Rio De Janeiro, Brazil
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 05期
关键词：
bone metastases; histological subtype; incidence; lung cancer; skeletal-related events; ZOLEDRONIC ACID; SOLID TUMORS; SURVIVAL; PREDICTORS; DENOSUMAB; SRES;
D O I：
10.2217/fon-2018-0613
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: Estimate the incidence of bone metastases (BM) and skeletal-related events according to the histological subtype of lung cancer and its impact on patient survival. Patients & methods: Retrospective cohort study was carried out with patients diagnosed with lung cancer. Cumulative incidence, Kaplan-Meier survival analysis and the risk of death were estimated. Results: In non-small-cell lung cancer (NSCLC), the cumulative incidence of BM during follow-up was 23.8% at 24 months; in small-cell lung cancer, it was 18.5%. The presence of BM in patients with NSCLC was associated with an increased risk of death (hazard ratio: 1.25; 95% CI: 1.04-1.49; p=0.013). Conclusion: This study revealed a high incidence of BM and skeletal-related events. BM was associated with a poor prognosis in NSCLC patients.
引用
收藏
页码：485 / 494
页数：10
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