Controlled trial of N-acetyleysteine for patients with probable Alzheimer's disease

被引：189
作者：
Adair, JC
Knoefel, JE
Morgan, N
机构：
[1] Univ New Mexico, Sch Med, Dept Neurol, Albuquerque, NM 87131 USA
[2] Vet Affairs Med Ctr, Neurol Serv, Albuquerque, NM USA
[3] Vet Affairs Med Ctr, Geriatr Serv, Albuquerque, NM USA
[4] Univ New Mexico, Dept Internal Med, Albuquerque, NM 87131 USA
[5] Vet Affairs Cooperat Studies Pharm, Albuquerque, NM USA
来源：
NEUROLOGY | 2001年 / 57卷 / 08期
关键词：
D O I：
10.1212/WNL.57.8.1515
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The antioxidant N-acetylcysteine (NAG) or placebo was administered in a double-blind fashion to patients who met National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for probable AD. Testing for efficacy occurred after 3 and 6 months of treatment. Comparison of interval change favored NAC treatment on nearly every outcome measure, although significant differences were obtained only for a subset of cognitive tasks.
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页码：1515 / 1517
页数：3
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