Boronate-Mediated Biologic Delivery

被引：199

作者：

Ellis, Gregory A. ^{[1
]}

Palte, Michael J. ^{[2
,3
]}

Raines, Ronald T. ^{[1
,4
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[2] Univ Wisconsin, Med Scientist Training Program, Madison, WI 53706 USA

[3] Univ Wisconsin, Mol & Cellular Pharmacol Grad Training Program, Madison, WI 53706 USA

[4] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 08期

关键词：

DRUG-DELIVERY; RIBONUCLEASE INHIBITOR; PHENYLBORONIC ACID; CELL-MEMBRANE; EFFICIENT; RECEPTOR; PROTEIN; CANCER; THERAPEUTICS; THERAPY;

D O I：

10.1021/ja210719s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic delivery of a protein toxin. Thus, boronates are a noncationic carrier that can deliver a polar macromolecule into mammalian cells.

引用

页码：3631 / 3634

页数：4

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