Influence of nanomedicine mechanical properties on tumor targeting delivery

被引：161

作者：

Li, Zheng ^{[1
]}

Xiao, Chen ^{[1
]}

Yong, Tuying ^{[1
]}

Li, Zifu ^{[1
,2
,3
]}

Gan, Lu ^{[1
,2
,3
]}

Yang, Xiangliang ^{[1
,2
,3
]}

机构：

[1] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Engn Res Ctr Nanomed, 1037 Luoyu Rd, Wuhan 430074, Peoples R China

[2] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Minist Educ, Key Lab Mol Biophys, 1037 Luoyu Rd, Wuhan 430074, Peoples R China

[3] Huazhong Univ Sci & Technol, Hubei Key Lab Bioinorgan Chem & Mat Med, 1037 Luoyu Rd, Wuhan 430074, Peoples R China

来源：

CHEMICAL SOCIETY REVIEWS | 2020年 / 49卷 / 08期

基金：

美国国家科学基金会;

关键词：

HYDROGEL PARTICLES; STIFFNESS; NANOPARTICLES; CIRCULATION; ELASTICITY; RIGIDITY; CELLS; PHAGOCYTOSIS; FORCES; SOFTER;

D O I：

10.1039/c9cs00575g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Modulating nanomedicine mechanical properties for enhanced drug delivery to tumors has attracted increasing attention in the past few decades. In this tutorial review, we analyze the impact of nanomedicine mechanical properties on in vivo transport processes and highlight the most recent advances in drug delivery efficiency and antitumor efficacy. Typical nanoparticles that have been explored for this purpose since 2000 are summarized while the methods to tune and the techniques to characterize nanomedicine mechanical properties are introduced. In the end, challenges and perspectives on tailoring nanomedicine mechanical properties for tumor targeting delivery are discussed.

引用

页码：2273 / 2290

页数：18

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