Association between ERCC5 gene polymorphisms and breast cancer risk

被引：0
作者：
Na, Nari [1 ,2 ]
Dun, Eer [3 ]
Ren, Lidong [2 ]
Li, Guoxin [1 ]
机构：
[1] Southern Med Univ, Nanfang Hosp, Dept Gen Surg, Guangzhou, Guangdong, Peoples R China
[2] Inner Mongolia Peoples Hosp, Dept Thyroid Breast Hernia & Vasc Surg, Hohhot, Peoples R China
[3] Inner Mongolia Peoples Hosp, Dept Resp, Hohhot, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 03期
关键词：
ERCC5; polymorphism; breast cancer; NUCLEOTIDE-EXCISION-REPAIR; OXIDATIVE DNA-DAMAGE; CIGARETTE-SMOKING; XPG; SUSCEPTIBILITY; METAANALYSIS; INVOLVEMENT; CARCINOMA; LUNG;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We conducted a case-control study to evaluate the association between ERCC5 polymorphism and breast cancer risk. 325 breast cancer patients and 325 controls were recruited in our study between January 2011 and March 2014. ERCC5 rs1047768, rs2094258, rs2296147, rs751402 and rs873601 polymorphisms were genotyped, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. By logistic regression analysis, we found that individuals with AA genotype of rs2094258 was associated with increased risk of breast cancer when compared with wide-type genotype, and the OR (95% CI) was 1.80 (1.12-2.92) for AA genotype. Individuals with GA + GG genotype of rs2094258 were significantly correlated with increased risk of breast cancer in tobacco smokers, and the OR (95% CI) was 7.35 (1.21-47.20). In conclusion, our study indicated that ERCC5 rs2094258 polymorphism may contribute to the risk of breast cancer.
引用
收藏
页码：3192 / 3197
页数：6
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