Vitamin K in COVID-19-Potential Anti-COVID-19 Properties of Fermented Milk Fortified with Bee Honey as a Natural Source of Vitamin K and Probiotics

被引:10
作者
Ali, Amira Mohammed [1 ,2 ]
Kunugi, Hiroshi [3 ,4 ]
Abdelmageed, Hend A. [5 ,6 ]
Mandour, Ahmed S. [7 ,8 ]
Ahmed, Mostafa Elsayed [9 ,10 ]
Ahmad, Saboor [11 ]
Hendawy, Amin Omar [12 ,13 ]
机构
[1] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Behav Med, 4-1-1 Ogawahigashi, Kodaira, Tokyo 1878553, Japan
[2] Alexandria Univ, Fac Nursing, Dept Psychiat Nursing & Mental Hlth, Alexandria 21527, Egypt
[3] Teikyo Univ, Sch Med, Dept Psychiat, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan
[4] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, 4-1-1 Ogawahigashi, Kodaira, Tokyo 1878502, Japan
[5] Agr Res Ctr, Ismailia Lab, Anim Hlth Res Inst, Dept Bacteriol, Ismailia 41511, Egypt
[6] Tokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, Lab Vet Microbiol, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan
[7] Suez Canal Univ, Fac Vet Med, Dept Anim Med Internal Med, Ring Rd, Ismailia 41522, Egypt
[8] Tokyo Univ Agr & Technol, Dept Vet Med, Tokyo 1838509, Japan
[9] Damanhour Univ, Dept Plant Protect, Fac Agr, Damanhour 22516, Egypt
[10] Chinese Acad Agr Sci, Inst Apiculture Res, Beijing 100081, Peoples R China
[11] Chinese Acad Agr Sci, Key Lab Pollinating Insect Biol, Minist Agr, Inst Apiculture Res, Beijing 100081, Peoples R China
[12] Damanhour Univ, Dept Anim & Poultry Prod, Fac Agr, Damanhour 22516, Egypt
[13] Tokyo Univ Agr & Technol, Dept Biol Prod, Tokyo 1838509, Japan
来源
FERMENTATION-BASEL | 2021年 / 7卷 / 04期
关键词
vitamin K; phylloquinone; menaquinones; Coronavirus disease 2019; COVID-19; fermented milk; yogurt; dairy products; milk peptides; honey; probiotics; in silico; in vitro; vitamin K antagonists; thrombosis; coagulopathy; oral anticoagulant therapy; calcium metabolism; elastic fiber degradation; antioxidants; phenols; MATRIX GLA-PROTEIN; CORONARY-ARTERY CALCIUM; MENAQUINONE-7; SUPPLEMENTATION; COGNITIVE DYSFUNCTION; ANTIOXIDANT ACTIVITY; GUT MICROBIOTA; DIETARY-INTAKE; COVID-19; MORTALITY; YOGURT;
D O I
10.3390/fermentation7040202
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Vitamin K deficiency is evident in severe and fatal COVID-19 patients. It is associated with the cytokine storm, thrombotic complications, multiple organ damage, and high mortality, suggesting a key role of vitamin K in the pathology of COVID-19. To support this view, we summarized findings reported from machine learning studies, molecular simulation, and human studies on the association between vitamin K and SARS-CoV-2. We also investigated the literature for the association between vitamin K antagonists (VKA) and the prognosis of COVID-19. In addition, we speculated that fermented milk fortified with bee honey as a natural source of vitamin K and probiotics may protect against COVID-19 and its severity. The results reported by several studies emphasize vitamin K deficiency in COVID-19 and related complications. However, the literature on the role of VKA and other oral anticoagulants in COVID-19 is controversial: some studies report reductions in (intensive care unit admission, mechanical ventilation, and mortality), others report no effect on mortality, while some studies report higher mortality among patients on chronic oral anticoagulants, including VKA. Supplementing fermented milk with honey increases milk peptides, bacterial vitamin K production, and compounds that act as potent antioxidants: phenols, sulforaphane, and metabolites of lactobacilli. Lactobacilli are probiotic bacteria that are suggested to interfere with various aspects of COVID-19 infection ranging from receptor binding to metabolic pathways involved in disease prognosis. Thus, fermented milk that contains natural honey may be a dietary manipulation capable of correcting nutritional and immune deficiencies that predispose to and aggravate COVID-19. Empirical studies are warranted to investigate the benefits of these compounds.
引用
收藏
页数:23
相关论文
共 152 条
[1]  
Al-Jabri AA, 2005, AFR J BIOTECHNOL, V4, P1580
[2]   Endocrine roles of vitamin K-dependent- osteocalcin in the relation between bone metabolism and metabolic disorders [J].
Al-Suhaimi, Ebtesam Abdullah ;
Al-Jafary, Meneerah Abdulrahman .
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2020, 21 (01) :117-125
[3]  
Alabboud M, 2020, DYSONA LIFE SCI, V1, P44
[4]  
Ali A.M., 2021, BioMed, V1, P11, DOI DOI 10.3390/BIOMED1010002
[5]  
Ali AM, 2018, JOJ Nurse Health Care, V9, DOI [10.19080/jojnhc.2018.09.555764, DOI 10.19080/JOJNHC.2018.09.555764]
[6]  
Ali AM, 2021, Med Leg Update, V21, P163, DOI [10.37506/mlu.v21i2.2665, DOI 10.37506/MLU.V21I2.2665]
[7]   The Effects of Royal Jelly Acid, 10-Hydroxy-trans-2-decenoic Acid, on Neuroinflammation and Oxidative Stress in Astrocytes Stimulated with Lipopolysaccharide and Hydrogen Peroxide [J].
Ali, Amira Mohammed ;
Kunugi, Hiroshi .
IMMUNO, 2021, 1 (03) :212-222
[8]   Bee honey and exercise for improving physical performance, reducing fatigue, and promoting an active lifestyle during COVID-19 [J].
Ali, Amira Mohammed ;
Ali, Esraa Mohammed ;
Abou Mousa, Alaaeldin ;
Ahmed, Mostafa Elsayed ;
Hendawy, Amin Omar .
SPORTS MEDICINE AND HEALTH SCIENCE, 2021, 3 (03) :177-180
[9]   Screening for Sarcopenia (Physical Frailty) in the COVID-19 Era [J].
Ali, Amira Mohammed ;
Kunugi, Hiroshi .
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2021, 2021
[10]   Skeletal Muscle Damage in COVID-19: A Call for Action [J].
Ali, Amira Mohammed ;
Kunugi, Hiroshi .
MEDICINA-LITHUANIA, 2021, 57 (04)