Betaglycan: A multifunctional accessory

被引：91

作者：

Bilandzic, Maree ^{[1
]}

Stenvers, Kaye L. ^{[1
]}

机构：

[1] Prince Henrys Inst, Clayton, Vic 3168, Australia

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2011年 / 339卷 / 1-2期

关键词：

Betaglycan; TGF beta receptor III; Inhibin; GROWTH-FACTOR-BETA; III TGF-BETA; INHIBIN-ALPHA-SUBUNIT; TUMOR-SUPPRESSOR GENE; RECEPTOR-TYPE-III; LIGAND-BINDING; CORECEPTOR BETAGLYCAN; MEMBRANE PROTEOGLYCAN; MUTATIONAL ANALYSIS; OVARIAN-CANCER;

D O I：

10.1016/j.mce.2011.04.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Betaglycan is a co-receptor for the TGF beta superfamily, particularly important in establishing the potency of its ligands on their target cells. In recent years, new insights have been gained into the structure and function of betaglycan, expanding its role from that of a simple co-receptor to include additional ligand-dependent and ligand-independent roles. This review focuses on recent advances in the betaglycan field, with a particular emphasis on its newly discovered actions in mediating the trafficking of TGF beta superfamily receptors and as a determinant of the functional output of TGF beta superfamily signalling. In addition, this review encompasses a discussion of the emerging roles of the betaglycan/inhibin pathway in reproductive cancers and disease. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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页码：180 / 189

页数：10

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