Clinical trial participation by adolescents and young adults with cancer: A continued cause for concern?

被引：7

作者：

White, Victoria ^{[1
,2
]}

Skaczkowski, Gemma ^{[1
,3
,4
]}

Anazodo, Antoinette ^{[7
,8
,9
]}

Bibby, Helen ^{[1
]}

Nicholls, Wayne ^{[15
]}

Pinkerton, Ross ^{[15
]}

Thompson, Kate ^{[5
]}

Orme, Lisa M. ^{[5
,6
]}

Conyers, Rachel ^{[5
,6
,14
]}

Osborn, Michael ^{[11
]}

Phillips, Marianne B. ^{[10
]}

Harrup, Rosemary ^{[12
]}

Walker, Rick ^{[15
,16
]}

Coory, Michael ^{[13
]}

机构：

[1] Canc Council Victoria, Ctr Behav Res Canc, 615 St Kilda Rd, Melbourne, Vic 3004, Australia

[2] Deakin Univ, Sch Psychol, Geelong, Vic, Australia

[3] La Trobe Univ, Sch Psychol & Publ Hlth, Melbourne, Vic, Australia

[4] Austin Hlth, Olivia Newton John Canc Wellness & Res Ctr, Heidelberg, Vic, Australia

[5] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[6] Royal Childrens Hosp, Childrens Canc Ctr, Parkville, Vic, Australia

[7] Sydney Childrens Hosp, Kids Canc Ctr, Randwick, NSW, Australia

[8] Prince Wales Hosp, Nelune Comprehens Canc Ctr, Randwick, NSW, Australia

[9] Univ New South Wales, Sch Womens & Childrens Hlth, Sydney, NSW, Australia

[10] Princess Margaret Hosp Children, Subiaco, WA, Australia

[11] Royal Adelaide Hosp, Adelaide, SA, Australia

[12] Royal Hobart Hosp, Hobart, Tas, Australia

[13] Univ Melbourne, Fac Med Dent & Hlth Sci, Melbourne, Vic, Australia

[14] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic, Australia

[15] Childrens Hlth Queensland Hosp & Hlth Serv, South Brisbane, Qld, Australia

[16] Princess Alexandra Hosp, Woolloongabba, Qld, Australia

来源：

SEMINARS IN ONCOLOGY | 2018年 / 45卷 / 5-6期

基金：

英国医学研究理事会;

关键词：

Adolescents and young adults; AYA; Cancer; Clinical trials; AYA ONCOLOGY PATIENTS; ENROLLMENT; SURVIVAL; RATES;

D O I：

10.1053/j.seminoncol.2018.04.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

International data indicate that rates of clinical trial enrolment for Adolescents and Young Adults (AYAs) with cancer are markedly lower than for any other age group. This paper reviews the recent literature reporting international trends in clinical trial enrolment since 2010. Subsequently, we present the first population-based, national assessment of clinical trial enrolment for AYAs with cancer in Australia. Reported rates of trial enrolment from Australia, Canada, the United States, and the United Kingdom were variable, though consistently low, ranging between 2% and 29%. Trial enrolment was higher for younger AYAs (typically 15-19 years) and those attending pediatric hospitals, and this was replicated in the recent Australian data. The findings highlight a lack of substantial improvement in AYA clinical trial enrolment and in particular, a need for improved opportunities to access trials for patients treated at adult centers. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：275 / 283

页数：9

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