Background: The present study investigated the effects of a 12-month interdisciplinary standardized lifestyle program addressing physical activity and changes in dietary and lifestyle behavior in 2,227 obese prediabetic participants. Methods: Measures of obesity (BMI, waist circumference), cardiopulmonary fitness, and metabolic parameters were determined before and after the intervention period. Results: From the 2,227 participants who were initially prediabetic, 839 participants (-37.7%) did no longer show the criteria of prediabetes after the intervention and had normal HbA1c levels. Conclusion: The clinical effects are substantial, and it is likely that the applied intense and multidisciplinary lifestyle interventions could reduce the risk of developing diabetes and the prevalence of a full-blown metabolic syndrome in obese and prediabetic patients. (c) 2018 The Author(s) Published by S. Karger GmbH, Freiburg
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Dusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, GermanyDusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, Germany
Roehling, Martin
Kempf, Kerstin
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Dusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, GermanyDusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, Germany
Kempf, Kerstin
Banzer, Winfried
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Goethe Univ Frankfurt, Inst Sports & Sport Sci, Dept Sports Med, D-60487 Frankfurt, GermanyDusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, Germany
Banzer, Winfried
Berg, Aloys
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Univ Freiburg, Fac Med, D-79117 Freiburg, GermanyDusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, Germany
Berg, Aloys
Braumann, Klaus-Michael
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Univ Hamburg, Fac Psychol & Human Movement Sci, Dept Sports & Movement Med, D-20148 Hamburg, GermanyDusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, Germany
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London Metropolitan Univ, Publ Hlth Nutr Res Grp, London N7 8DB, EnglandDusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, Germany
McCarthy, David
Pinget, Michel
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Univ Strasbourg, Dept Endocrinol Diabet & Malad Metab, Fac Med, F-67170 Strasbourg, FranceDusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, Germany
Pinget, Michel
Predel, Hans-Georg
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German Sport Univ Cologne, Inst Cardiovasc Res & Sports Med, D-50933 Cologne, GermanyDusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, Germany
Predel, Hans-Georg
Scholze, Juergen
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KARDIOS, Cardioligists Berlin, D-10787 Berlin, GermanyDusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, Germany
Scholze, Juergen
Toplak, Hermann
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Med Univ Graz, Dept Med, Div Endocrinol, A-8010 Graz, AustriaDusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, Germany
Toplak, Hermann
Martin, Stephan
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Dusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, Germany
Heinrich Heine Univ Dusseldorf, Fac Med, D-40591 Dusseldorf, GermanyDusseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, D-40591 Dusseldorf, Germany
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Tufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USATufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USA
Salinardi, Taylor C.
Batra, Payal
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Tufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USATufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USA
Batra, Payal
Roberts, Susan B.
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Tufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USATufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USA
Roberts, Susan B.
Urban, Lorien E.
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Tufts Univ, Energy Metab Lab, Boston, MA 02111 USATufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USA
Urban, Lorien E.
Robinson, Lisa M.
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Boston Childrens Hosp, New Balance Fdn Obes Prevent Cntr, Boston, MA USATufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USA
Robinson, Lisa M.
Pittas, Anastassios G.
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Tufts Med Cntr, Div Endocrinol Diabet & Metab, Boston, MA USATufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USA
Pittas, Anastassios G.
Lichtenstein, Alice H.
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Tufts Univ, Cardiovasc Nutr Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USATufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USA
Lichtenstein, Alice H.
Deckersbach, Thilo
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Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA USATufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USA
Deckersbach, Thilo
Saltzman, Edward
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Tufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USATufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USA
Saltzman, Edward
Das, Sai Krupa
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Tufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USATufts Univ, Energy Metab Lab, Jean Mayer USDA Human Nutr Rsch Cntr Aging, Boston, MA 02111 USA