Scalalactams A-D, Scalarane Sesterterpenes with a -Lactam Moiety from a Korean Spongia Sp. Marine Sponge

被引：13

作者：

Yang, Inho ^{[1
]}

Lee, Jusung ^{[2
]}

Lee, Jihye ^{[2
]}

Hahn, Dongyup ^{[3
,4
]}

Chin, Jungwook ^{[5
]}

Won, Dong Hwan ^{[2
]}

Ko, Jaeyoung ^{[6
]}

Choi, Hyukjae ^{[7
]}

Hong, Ahreum ^{[8
]}

Nam, Sang-Jip ^{[9
]}

Kang, Heonjoong ^{[2
,10
]}

机构：

[1] Korea Maritime & Ocean Univ, Dept Convergence Study Ocean Sci & Technol, Busan 49112, South Korea

[2] Seoul Natl Univ, Ctr Marine Nat Prod & Drug Discovery, Sch Earth & Environm Sci, NS-80, Seoul 08826, South Korea

[3] Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea

[4] Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea

[5] Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea

[6] Amorepacific R&D Unit, Basic Res & Innovat Div, Yongin 17074, South Korea

[7] Yeungnam Univ, Coll Pharm, Gyongsan 38541, South Korea

[8] Ewha Womans Univ, Grad Sch Ind Pharmaceut Sci, Seoul 03760, South Korea

[9] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea

[10] Seoul Natl Univ, Res Inst Oceanog, NS-80, Seoul 08826, South Korea

来源：

MOLECULES | 2018年 / 23卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

scalarane sesterterpenes; scalalactams; marine natural products; marine sponge; Spongia sp; PYRROLOTERPENE; METABOLITES;

D O I：

10.3390/molecules23123187

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intensive study on the chemical components of a Korean marine sponge, Spongia sp., has led to the isolation of four new scalarane sesterterpenes, scalalactams A-D (1-4). Their chemical structures were elucidated from the analysis of spectroscopic data including 1D-and 2D-NMR as well as MS data. Scalalactams A-D (1-4) possess a scalarane carbon skeleton with a rare structural feature of a -lactam moiety within the molecules. Scalalactams A and B (1 and 2) have an extended isopropanyl chain at the lactam ring, and scalalactams C and D (3 and 4) possess a phenethyl group at the lactam ring moiety. Scalalactams A-D (1-4) did not show FXR antagonistic activity nor cytotoxicity up to 100 M.

引用

页数：10

共 38 条

[1] Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene [J].