HisgAtlas 1.0: a human immunosuppression gene database

被引：36

作者：

Liu, Yuan ^{[1
]}

He, Mengqi ^{[1
]}

Wang, Dan ^{[1
]}

Diao, Lihong ^{[1
]}

Liu, Jinying ^{[2
]}

Tang, Li ^{[1
]}

Guo, Shuzhen ^{[2
]}

He, Fuchu ^{[1
]}

Li, Dong ^{[1
]}

机构：

[1] Beijing Inst Life, Beijing Proteome Res Ctr, Natl Ctr Prot Sci, State Key Lab Prote, Beijing 102206, Peoples R China

[2] Beijing Univ Chinese Med, Sch Chinese Med, Beijing 100029, Peoples R China

来源：

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | 2017年

关键词：

IMMUNE; BLOCKADE; ONTOLOGY;

D O I：

10.1093/database/bax094

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immunosuppression is body's state in which the activation or efficacy of immune system is weakened. It is associated with a wide spectrum of human diseases. In the last two decades, tremendous efforts have been made to elucidate the mechanism of hundreds of immunosuppression genes. Immunosuppression genes could be valuable drug targets or biomarkers for the immunotherapeutic treatment of different diseases. However, the information of all previously identified immunosuppression genes is dispersed in thousands of publications. Here, we provide the HisgAtlas database that collects 995 previously identified human immunosuppression genes using text mining and manual curation. We believe HisgAtlas will be a valuable resource to search human immunosuppression genes as well as to investigate their functions in further research.

引用

页数：6

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