Functions of Polyamines in Mammals

被引:511
作者
Pegg, Anthony E. [1 ]
机构
[1] Penn State Univ, Milton S Hershey Med Ctr, Dept Cellular & Mol Physiol, Coll Med, Hershey, PA 17033 USA
关键词
SPERMINE SYNTHASE GENE; S-ADENOSYLMETHIONINE DECARBOXYLASE; RECTIFYING POTASSIUM CHANNEL; L-ORNITHINE DECARBOXYLASE; SNYDER-ROBINSON SYNDROME; TRANSLATION FACTOR EIF5A; REGENERATING RAT-LIVER; D-ASPARTATE RECEPTOR; FACTOR 5A EIF5A; GLUTAMATE RECEPTORS;
D O I
10.1074/jbc.R116.731661
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The content of spermidine and spermine in mammalian cells has important roles in protein and nucleic acid synthesis and structure, protection from oxidative damage, activity of ion channels, cell proliferation, differentiation, and apoptosis. Spermidine is essential for viability and acts as the precursor of hypusine, a post-translational addition to eIF5A allowing the translation ofmRNAsencoding proteins containing polyproline tracts. Studies with Gy mice and human patients with the very rare X-linked genetic condition Snyder-Robinson syndrome that both lack spermine synthase show clearly that the correct spermine: spermidine ratio is critical for normal growth and development.
引用
收藏
页码:14904 / 14912
页数:9
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