Therapy-related acute myeloid leukemia: role of DNA repair

被引：0

作者：

Guieze, Romain ^{[1
,2
]}

Ravinet, Aurelie ^{[2
]}

Hermet, Eric ^{[2
]}

Maliki, Yassine ^{[2
]}

de Botton, Stephane ^{[3
]}

Bay, Jacques-Olivier ^{[1
,2
]}

机构：

[1] Univ Clermont I, EA 3846, F-63001 Clermont Ferrand, France

[2] CHU Clermont Ferrand, Hop Estaing, Serv Hematol Clin Adulte & Therapie Cellulaire, F-63000 Clermont Ferrand, France

[3] Inst Gustave Roussy, Serv Hematol Clin, F-94805 Villejuif, France

来源：

BULLETIN DU CANCER | 2011年 / 98卷 / 03期

关键词：

therapy-related acute myeloid leukemia; DNA repair; leukemogenesis; ACUTE MYELOGENOUS LEUKEMIA; CHROMOSOMAL TRANSLOCATIONS; TOPOISOMERASE-II; MICROSATELLITE INSTABILITY; MYELODYSPLASTIC SYNDROME; FUSION PROTEINS; BREAST-CANCER; P53; MUTATIONS; RISK; INCREASE;

D O I：

10.1684/bdc.2011.1325

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The survival improvement of patients treated with chemotherapy or radiotherapy for malignancies are increasing therapy-related acute myeloid leukemia (t-AML). It was thought to be the direct consequence of genetic events induced by such treatments. We here review the mechanisms of specific chemotherapy-related DNA damage inducing the chromosomal or genomic abnormalities characteristic of t-AML. We also focus on how such aberrations could initiate or participate to leukemogenesis. However, only a part of patients exposed to cytotoxic therapy is developing t-AML, suggesting that some genetic predisposition may be involved such as polymorphisms in genes related to DNA repair. triangle

引用

页码：247 / 255

页数：9

共 33 条

[1] Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair [J].

Alcalay, M ;

Meani, N ;

Gelmetti, V ;

Fantozzi, A ;

Fagioli, M ;

Orleth, A ;

Riganelli, D ;

Sebastiani, C ;

Cappelli, E ;

Casciari, C ;

Sciurpi, MT ;

Mariano, AR ;

Minardi, SP ;

Luzi, L ;

Muller, H ;

Di Fiore, PP ;

Frosina, G ;

Pelicci, PG .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (11) :1751-1761

[2] Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy [J].

Allan, JM ;

Smith, AG ;

Wheatley, K ;

Hills, RK ;

Travis, LB ;

Hill, DA ;

Swirsky, DM ;

Morgan, GJ ;

Wild, CP .

BLOOD, 2004, 104 (13) :3872-3877

[3] Therapy-related acute promyelocytic leukemia [J].

Beaumont, M ;

Sanz, M ;

Carli, PM ;

Maloisel, F ;

Thomas, X ;

Detourmignies, L ;

Guerci, A ;

Gratecos, N ;

Rayon, C ;

Miguel, JS ;

Odriozola, J ;

Cahn, JY ;

Huguet, F ;

Vekhof, A ;

Stamatoulas, A ;

Dombret, H ;

Capote, F ;

Esteve, J ;

Stoppa, AM ;

Fenaux, P .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (11) :2123-2137

[4]

BenYehuda D, 1996, BLOOD, V88, P4296

[5] Proliferation is necessary for both repair and mutation in transgenic mouse cells [J].

Bielas, JH ;

Heddle, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (21) :11391-11396

[6] Survival Is Poorer in Patients With Secondary Core-binding Factor Acute Myelogenous Leukemia Compared With De Novo Core-binding Factor Leukemia [J].

Borthakur, Gautam ;

Lin, E. ;

Jain, Nitin ;

Estey, Elihu E. ;

Cortes, Jorge E. ;

O'Brien, Susan ;

Faderl, Stefan ;

Ravandi, Farhad ;

Pierce, Sherry ;

Kantarjian, Hagop .

CANCER, 2009, 115 (14) :3217-3221

[7] Predisposition to therapy-related acute leukemia with balanced chromosomal translocations does not result from a major constitutive defect in DNA double-strand break end joining [J].

Coiteux, Valerie ;

Onclercq-Delic, Rosine ;

Fenaux, Pierre ;

Amor-Gueret, Mounira .

LEUKEMIA RESEARCH, 2007, 31 (03) :353-358

[8] Treatment-related Myelodysplastic syndrome and acute myelogenous leukemia in patients treated with ibritumomab tiuxetan radioimmunotherapy [J].

Czuczman, Myron S. ;

Emmanouilides, Christos ;

Darif, Mohamed ;

Witzig, Thomas E. ;

Gordon, Leo I. ;

Revell, Stephen ;

Vo, Katie ;

Molina, Arturo .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (27) :4285-4292

[9] Engineering de novo reciprocal chromosomal translocations associated with MII to replicate primary events of human cancer [J].

Forster, A ;

Pannell, R ;

Drynan, LF ;

McCormack, M ;

Collins, EC ;

Daser, A ;

Rabbitts, TH .

CANCER CELL, 2003, 3 (05) :449-458

[10] Does autologous transplantation directly increase the risk of secondary leukemia in lymphoma patients? [J].

Hake, C. R. ;

Graubert, T. A. ;

Fenske, T. S. .

BONE MARROW TRANSPLANTATION, 2007, 39 (02) :59-70

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