New players in the regulation of ecdysone biosynthesis

被引：118

作者：

Huang, Xun ^{[1
]}

Warren, James T. ^{[2
]}

Gilbert, Lawrence I. ^{[2
]}

机构：

[1] Chinese Acad Sci, Mol & Dev Biol Lab, Inst Genet & Dev Biol, Beijing 100101, Peoples R China

[2] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF GENETICS AND GENOMICS | 2008年 / 35卷 / 01期

基金：

美国国家科学基金会;

关键词：

ecdysone; cholesterol; PTTH; P450;

D O I：

10.1016/S1673-8527(08)60001-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insect ecdysone steroid hormone regulates major developmental transitions, such as molting and metamorphosis. The production of ecdysone correlates well with the timing of these transitions. Finding out how the ecdysone biosynthesis is regulated is crucial to fully understand these sophisticated developmental switches. Here we summarized recent findings in the regulation of ecdysone biosynthesis from the aspects of cell signaling, key biosynthetic enzymes and substrate cholesterol trafficking.

引用

页码：1 / 10

页数：10

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