The expression and prognostic significance of hepatoma-derived growth factor in oral cancer

被引：29

作者：

Lin, Yu-Wei ^{[1
,2
]}

Li, Chien-Feng ^{[1
,3
]}

Chen, Hsuan-Yu ^{[4
]}

Yen, Ching-Yu ^{[5
,7
]}

Lin, Li-Ching ^{[2
]}

Huang, Chao-Cheng ^{[6
]}

Huang, Hsuan-Ying ^{[6
]}

Wu, Ping-Ching ^{[8
,9
]}

Chen, Chang-Han ^{[10
]}

Chen, San-Cher ^{[1
,11
]}

Tai, Ming-Hong ^{[1
,4
,11
]}

机构：

[1] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung 804, Taiwan

[2] Chi Mei Med Ctr, Div Oral & Maxillofacial Surg, Dept Radiat Oncol, Tainan, Taiwan

[3] Chi Mei Med Ctr, Div Oral & Maxillofacial Surg, Dept Pathol, Tainan, Taiwan

[4] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 804, Taiwan

[5] Chi Mei Med Ctr, Div Oral & Maxillofacial Surg, Dept Dent, Tainan, Taiwan

[6] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Kaohsiung Med Ctr,Dept Pathol, Kaohsiung, Taiwan

[7] Taipei Med Univ, Dept Dent, Taipei, Taiwan

[8] Natl Cheng Kung Univ, Inst Oral Med, Tainan 70101, Taiwan

[9] Natl Cheng Kung Univ, Dept Stomatol, Tainan 70101, Taiwan

[10] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Kaohsiung Med Ctr,Dept Otolaryngol, Kaohsiung, Taiwan

[11] Natl Sun Yat Sen Univ, Ctr Neurosci, Kaohsiung 804, Taiwan

来源：

ORAL ONCOLOGY | 2012年 / 48卷 / 07期

关键词：

Hepatoma-derived growth factor (HDGF); Oral cancer; Head and neck cancer; Local recurrence-free survival; Tumor necrosis; SQUAMOUS-CELL CARCINOMA; LYMPH-NODE METASTASIS; GENE-EXPRESSION; HEAD; NECK; CHEMOTHERAPY; IRRADIATION; MYND; SET;

D O I：

10.1016/j.oraloncology.2012.01.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatoma-derived growth factor (HDGF) participates in oncogenic progression and represents a prognostic factor in several types of cancer. This study aimed to elucidate the role of HDGF during oral carcinogenesis. HDGF expression and the tumorigenic behaviors in human oral cell lines were investigated by immunoblotting, invasion and colony formation assays. Recombinant adenovirus vectors were employed to modulate the HDGF level in oral cancer cells. Immunohistochemical analysis using tissue microarray (TMA) consisting of surgically resected samples from 95 oral cancer patients was performed to delineate the correlation between HDGF expression and clinic-pathological parameters. HDGF expression was higher in malignant oral cancer cells than benign ones. Adenovirus-mediated HDGF overexpression and knockdown demonstrated the cellular HDGF level regulated the tumorigenic behaviors of oral cancer cells. Immunohistochemical analysis revealed increased HDGF expression in the nucleus and cytoplasm in oral cancer tissues. The nuclear HDGF expression was significantly correlated with tumor stage (P = 0.004) and grade (P = 0.013) while the cytoplasmic HDGF expression was associated with tumor necrosis (P = 0.002). Kaplan-Meier analysis revealed that patients with high nuclear HDGF expression had significantly worse 5-year disease-specific survival (P = 0.0069), metastasis-free survival (P = 0.0168), and local recurrence-free survival (P = 0.0047). Multivariate analysis indicated that the nuclear HDGF labeling index was an independent prognostic factor for disease-specific and local recurrence-free survival. HDGF overexpression contributes to the oncogenic processes in oral cancer cells and constitutes a novel prognostic factor for survival outcome of oral cancer patients. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：629 / 635

页数：7

共 31 条

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