Low Levels of High-Density Lipoprotein Cholesterol Due to Lecithin: Cholesterol Acyltransferase Mutations Increase Carotid Atherosclerosis

被引：2

作者：

Fazio, Sergio ^{[1
]}

Linton, MacRae F. ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Div Cardiovasc Med, Atherosclerosis Res Unit, Nashville, TN 37232 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2011年 / 58卷 / 24期

关键词：

atherosclerosis; genetics; high-density lipoprotein; lecithin:cholesterol acyltransferase; magnetic resonance imaging; ESTER TRANSFER PROTEIN; CORONARY ATHEROSCLEROSIS; TRANSGENIC MICE; HIGH-RISK; HDL; TORCETRAPIB; DISEASE; ATHEROPROTECTION; PROGRESSION; EXPRESSION;

D O I：

10.1016/j.jacc.2010.11.091

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：2488 / 2490

页数：3

共 23 条

[1] Adenoviral expression of human lecithin-cholesterol acyltransferase in nonhuman primates leads to an antiatherogenic lipoprotein phenotype by increasing high-density lipoprotein and lowering low-density lipoprotein [J].

Amar, Marcelo J. A. ;

Shamburek, Robert D. ;

Vaisman, Boris ;

Knapper, Cathenine L. ;

Foger, Bernhard ;

Hoyt, Robert F., Jr. ;

Santamarina-Fojo, Silvia ;

Brewer, Hollis B., Jr. ;

Remaley, Alan T. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2009, 58 (04) :568-575

[2] Effects of torcetrapib in patients at high risk for coronary events [J].

Barter, Philip J. ;

Caulfield, Mark ;

Eriksson, Mats ;

Grundy, Scott M. ;

Kastelein, John J. P. ;

Komajda, Michel ;

Lopez-Sendon, Jose ;

Mosca, Lori ;

Tardif, Jean-Claude ;

Waters, David D. ;

Shear, Charles L. ;

Revkin, James H. ;

Buhr, Kevin A. ;

Fisher, Marian R. ;

Tall, Alan R. ;

Brewer, Bryan .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (21) :2109-2122

[3] High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin-cholesteryl acyltransferase [J].

Berard, AM ;

Foger, B ;

Remaley, A ;

Shamburek, R ;

Vaisman, BL ;

Talley, G ;

Paigen, B ;

Hoyt, RF ;

Marcovina, S ;

Brewer, HB ;

SantamarinaFojo, S .

NATURE MEDICINE, 1997, 3 (07) :744-749

[4] High plasma cholesteryl ester transfer protein levels may favour reduced incidence of cardiovascular events in men with low triglycerides [J].

Borggreve, Susanna E. ;

Hillege, Hans L. ;

Dallinga-Thie, Geesje M. ;

de Jong, Paul E. ;

Wolffenbuttel, Bruce H. R. ;

Grobbee, Diederik E. ;

van Tol, Arie ;

Dullaart, Robin P. F. .

EUROPEAN HEART JOURNAL, 2007, 28 (08) :1012-1018

[5] An increased coronary risk is paradoxically associated with common cholesteryl ester transfer protein gene variations that relate to higher high-density lipoprotein cholesterol: A population-based study [J].

Borggreve, Susanna E. ;

Hillege, Hans L. ;

Wolffenbuttel, Bruce H. R. ;

de Jong, Paul E. ;

Zuurman, Mike W. ;

van der Steege, Gerrit ;

van Tol, Arie ;

Dullaart, Robin P. F. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (09) :3382-3388

[6] Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial [J].

Bots, Michiel L. ;

Visseren, Frank L. ;

Evans, Gregory W. ;

Riley, Ward A. ;

Revkin, James H. ;

Tegeler, Charles H. ;

Shear, Charles L. ;

Duggan, William T. ;

Vicari, Ralph M. ;

Grobbee, Diederick E. ;

Kastelein, John J. .

LANCET, 2007, 370 (9582) :153-160

[7] The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes -: A comprehensive study of molecular and biochemical findings in 13 unrelated Italian families [J].

Calabresi, L ;

Pisciotta, L ;

Costantin, A ;

Frigerio, I ;

Eberini, I ;

Alessandrini, P ;

Arca, M ;

Bon, GB ;

Boscutti, G ;

Busnach, G ;

Frascà, G ;

Gesualdo, L ;

Gigante, M ;

Lupattelli, G ;

Montali, A ;

Pizzolitto, S ;

Rabbone, I ;

Rolleri, M ;

Ruotolo, G ;

Sampietro, T ;

Sessa, A ;

Vaudo, G ;

Cantafora, A ;

Veglia, F ;

Calandra, S ;

Bertolini, S ;

Franceschini, G .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (09) :1972-1978

[8] Lecithin: Cholesterol Acyltransferase, High-Density Lipoproteins, and Atheroprotection in Humans [J].

Calabresi, Laura ;

Franceschini, Guido .

TRENDS IN CARDIOVASCULAR MEDICINE, 2010, 20 (02) :50-53

[9] Functional Lecithin: Cholesterol Acyltransferase Is Not Required for Efficient Atheroprotection in Humans [J].

Calabresi, Laura ;

Baldassarre, Damiano ;

Castelnuovo, Samuela ;

Conca, Paola ;

Bocchi, Letizia ;

Candini, Chiara ;

Frigerio, Beatrice ;

Amato, Mauro ;

Sirtori, Cesare R. ;

Alessandrini, Paola ;

Arca, Marcello ;

Boscutti, Giuliano ;

Cattin, Luigi ;

Gesualdo, Loreto ;

Sampietro, Tiziana ;

Vaudo, Gaetano ;

Veglia, Fabrizio ;

Calandra, Sebastiano ;

Franceschini, Guido .

CIRCULATION, 2009, 120 (07) :628-635

[10] Safety of Anacetrapib in Patients with or at High Risk for Coronary Heart Disease. [J].

Cannon, Christopher P. ;

Shah, Sukrut ;

Dansky, Hayes M. ;

Davidson, Michael ;

Brinton, Eliot A. ;

Gotto, Antonio M., Jr. ;

Stepanavage, Michael ;

Liu, Sherry Xueyu ;

Gibbons, Patrice ;

Ashraf, Tanya B. ;

Zafarino, Jennifer ;

Mitchel, Yale ;

Barter, Philip .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (25) :2406-2415

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