A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease

被引：475

作者：

Anand, Preet ^{[1
]}

Singh, Baldev ^{[1
]}

Singh, Nirmal ^{[2
]}

机构：

[1] Punjabi Univ, Dept Chem, Patiala 147002, Punjab, India

[2] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2012年 / 20卷 / 03期

关键词：

Acetylcholinesterase inhibitor; Alzheimer disease; Coumarin; Benzylamino; PERIPHERAL SITE LIGANDS; MONOAMINE-OXIDASE; BIOLOGICAL EVALUATION; ANGELICA-GIGAS; HIGHLY POTENT; DERIVATIVES; HYPOTHESIS; DESIGN; MEMORY; BRAIN;

D O I：

10.1016/j.bmc.2011.12.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acetylcholinesterase (AChE) enzyme inhibition is an important target for the management of Alzheimer disease (AD) and AChE inhibitors are the main stay drugs for its management. Coumarins are the phytochemicals with wide range of biological activities including AChE inhibition. The scientists have attempted to explore the coumarin template for synthesizing novel AChE inhibitors with additional pharmacological activities including decrease in beta-amyloid (Ab) deposition and beta-secretase inhibition that are also important for AD management. Most of the designed schemes have involved incorporation of a catalytic site interacting moiety at 3- and 4-positions of the coumarin ring. The present review describes these differently synthesized coumarin derivatives as AChE inhibitors for management of AD. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1175 / 1180

页数：6

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