Invasive mycoses in children receiving hemopoietic SCT

被引：23
作者：
Castagnola, E. [1 ]
Faraci, M. [2 ]
Moroni, C. [3 ]
Bandettini, R. [3 ]
Granata, C. [4 ]
Caruso, S. [5 ]
Bagnasco, F. [5 ]
Caviglia, I. [1 ]
Malgorzata, M. [6 ]
Furfaro, E. [6 ]
Natalizia, A. R. [1 ]
de Fazio, V. [2 ]
Morreale, G.
Lanino, E. [2 ]
Haupt, R. [5 ]
Dini, G. [2 ]
Viscoli, C. [6 ]
机构：
[1] G Gaslini Inst Children, Dept Hematol & Oncol, Infect Dis Unit, I-16147 Genoa, Italy
[2] G Gaslini Inst Children, Bone Marrow Transplant Unit, I-16147 Genoa, Italy
[3] G Gaslini Inst Children, Microbiol Lab, I-16147 Genoa, Italy
[4] G Gaslini Inst Children, Serv Radiol, I-16147 Genoa, Italy
[5] G Gaslini Inst Children, Epidemiol & Biostat Sect, Sci Directorate, I-16147 Genoa, Italy
[6] Univ Genoa, San Martino Univ Hosp, Dept Hematol & Oncol, Div Infect Dis, Genoa, Italy
来源：
BONE MARROW TRANSPLANTATION | 2008年 / 41卷 / Suppl 2期
关键词：
epidemiology; invasive mycosis; HSCT; paediatrics;
D O I：
10.1038/bmt.2008.67
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Invasive mycoses represent a rare but severe complication following hemopoietic SCT (HSCT) in children. Their incidence is related to the type of donor, being higher after allogeneic transplant, especially from alternative donors. Moreover, the incidence of invasive mycoses varies in the different post transplant phases. Neutropenia, lymphopenia, GvHD, high-dose steroids or other immunosuppressive drugs represent well-known risk factors. The clinical features of invasive mycoses after HSCT in children are similar to those observed in adults, and the diagnostic tools, including Aspergillus galactomannan antigen detection, are feasible also in pediatrics. Mortality due to invasive mycoses after HSCT in children is high.
引用
收藏
页码：S107 / S111
页数：5
相关论文
共 48 条
  • [1] Refractory aspergillus pneumonia in patients with acute leukemia - Successful therapy with combination caspofungin and liposomal amphotericin
    Aliff, TB
    Maslak, PG
    Jurcic, JG
    Heaney, ML
    Cathcart, KN
    Sepkowitz, KA
    Weiss, MA
    [J]. CANCER, 2003, 97 (04) : 1025 - 1032
  • [2] Pathogenic Aspergillus species recovered from a hospital water system:: A 3-year prospective study
    Anaissie, EJ
    Stratton, SL
    Dignani, MC
    Summerbell, RC
    Rex, JH
    Monson, TP
    Spencer, T
    Kasai, M
    Francesconi, A
    Walsh, TJ
    [J]. CLINICAL INFECTIOUS DISEASES, 2002, 34 (06) : 780 - 789
  • [3] Computed tomography in the evaluation of febrile neutropenic pediatric oncology patients
    Archibald, S
    Park, J
    Geyer, JR
    Hawkins, DS
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2001, 20 (01) : 5 - 10
  • [4] Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: An international consensus
    Ascioglu, S
    Rex, JH
    de Pauw, B
    Bennett, JE
    Bille, J
    Crokaert, F
    Denning, DW
    Donnelly, JP
    Edwards, JE
    Erjavec, Z
    Fiere, D
    Lortholary, O
    Maertens, J
    Meis, JF
    Patterson, TF
    Ritter, J
    Selleslag, D
    Shah, PM
    Stevens, DA
    Walsh, TJ
    [J]. CLINICAL INFECTIOUS DISEASES, 2002, 34 (01) : 7 - 14
  • [5] Serious infections after unrelated donor transplantation in 136 children: Impact of stem cell source
    Barker, JN
    Hough, RE
    van Burik, JAH
    DeFor, TE
    MacMillan, ML
    O'Brien, MR
    Wagner, JE
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2005, 11 (05) : 362 - 370
  • [6] Detection of Aspergillus galactomannan antigenemia to determine biological and clinical implications of beta-lactam treatments
    Bart-Delabesse, E
    Basile, M
    Al Jijakli, A
    Souville, D
    Gay, F
    Philippe, B
    Bossi, P
    Danis, M
    Vernant, JP
    Datry, A
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (10) : 5214 - 5220
  • [7] Infections diagnosed in the first year after pediatric stem cell transplantation
    Benjamin, DK
    Miller, WC
    Bayliff, S
    Martel, L
    Alexander, KA
    Martin, PL
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2002, 21 (03) : 227 - 234
  • [8] Boeckh M., 2002, Clinical Approach to Infection in the Compromised Host, P527
  • [9] Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia
    Caillot, D
    Couaillier, JF
    Bernard, A
    Casasnovas, O
    Denning, DW
    Mannone, L
    Lopez, J
    Couillault, G
    Piard, F
    Vagner, O
    Guy, H
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (01) : 253 - 259
  • [10] Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery
    Caillot, D
    Casasnovas, O
    Bernard, A
    Couaillier, JF
    Durand, C
    Cuisenier, B
    Solary, E
    Piard, F
    Petrella, T
    Bonnin, A
    Couillault, G
    Dumas, M
    Guy, H
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (01) : 139 - 147
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