High-Throughput Screening Technology in Industrial Biotechnology

被引：231

作者：

Zeng, Weizhu ^{[1
,2
]}

Guo, Likun ^{[1
,2
,3
]}

Xu, Sha ^{[1
,2
,3
]}

Chen, Jian ^{[1
,2
,3
]}

Zhou, Jingwen ^{[1
,2
,3
]}

机构：

[1] Jiangnan Univ, Natl Engn Lab Cereal Fermentat Technol, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China

[2] Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Ind Biotechnol, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China

[3] Jiangnan Univ, Jiangsu Provis Res Ctr Bioact Prod Proc Technol, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China

来源：

TRENDS IN BIOTECHNOLOGY | 2020年 / 38卷 / 08期

基金：

中国国家自然科学基金;

关键词：

ENHANCED RAMAN-SCATTERING; TEMPERATURE PLASMA ARTP; L-LACTIC ACID; DIRECTED EVOLUTION; SINGLE-CELL; ACCURATE QUANTIFICATION; METABOLITE PRODUCTION; ASPERGILLUS-NIGER; BACILLUS-SUBTILIS; FLOW-CYTOMETRY;

D O I：

10.1016/j.tibtech.2020.01.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Based on the development of automatic devices and rapid assay methods, various high-throughput screening (HTS) strategies have been established for improving the performance of industrial microorganisms. We discuss the most significant factors that can improve HTS efficiency, including the construction of screening libraries with high diversity and the use of new detection methods to expand the search range and highlight target compounds. We also summarize applications of HTS for enhancing the performance of industrial microorganisms. Current challenges and potential improvements to HTS in industrial biotechnology are discussed in the context of rapid developments in synthetic biology, nanotechnology, and artificial intelligence. Rational integration will be an important driving force for constructing more efficient industrial microorganisms with wider applications in biotechnology.

引用

页码：888 / 906

页数：19

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