Oseltamivir resistance depends on the amino acid at the 273rd position of neuraminidase of influenza a virus (H1N1) circulating in the human population

被引：0

作者：

Ryabinin, V. A. ^{[1
]}

Kostina, E. V. ^{[1
]}

Sinyakov, A. N. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Novosibirsk 630090, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2011年 / 37卷 / 05期

关键词：

influenza A virus; neuraminidase; diagnostics; antiviral drugs; oseltamivir; resistance; MUTATION;

D O I：

10.1134/S1068162011050153

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of neuraminidase of influenza A virus (H1N1) spreading in the human population was analyzed. The results indicate a significant correlation between the virus sensitivity to oseltamivir and the nature of amino acids at positions 274 and 273 of neuraminidase. Phenylalanine at position 273 indicates a higher propensity of the influenza virus to mutation H274Y, which leads to resistant strains. It is suggested that the mutation at position 273 may be one of the characteristics that allow the type-A influenza virus to be ascribed to a pandemic or a seasonal type.

引用

页码：640 / 643

页数：4

共 8 条

[1]

Belyakova N. V., 2010, Voprosy Virusologii, V55, P10

[2] Development of a novel real-time reverse-transcriptase PCR method for the detection of H275Y positive influenza A H1N1 isolates [J].

Bolotin, S. ;

Robertson, A. V. ;

Eshaghi, A. ;

De Lima, C. ;

Lombos, E. ;

Chong-King, E. ;

Burton, L. ;

Mazzulli, T. ;

Drews, S. J. .

JOURNAL OF VIROLOGICAL METHODS, 2009, 158 (1-2) :190-194

[3] Rapid molecular detection of the H275Y oseltamivir resistance gene mutation in circulating influenza A (H1N1) viruses [J].

Carr, Michael J. ;

Sayre, Naomi ;

Duffy, Margaret ;

Connell, Jeff ;

Hall, William W. .

JOURNAL OF VIROLOGICAL METHODS, 2008, 153 (02) :257-262

[4] Rapid Genotypic Assay for Detection of Oseltamivir-Resistant Influenza A (H1N1) Viruses [J].

Hata, Mami ;

Tanaka, Seidai ;

Yasui, Yoshihiro ;

Fujiwara, Noriko ;

Kobayashi, Shinichi ;

Minagawa, Hiroko .

JOURNAL OF CLINICAL MICROBIOLOGY, 2010, 48 (05) :1983-1984

[5] Oseltamivir Resistance and the H274Y Neuraminidase Mutation in Seasonal, Pandemic and Highly Pathogenic Influenza Viruses [J].

Hurt, Aeron C. ;

Holien, Jessica K. ;

Parker, Michael W. ;

Barr, Ian G. .

DRUGS, 2009, 69 (18) :2523-2531

[6] The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo [J].

Ives, JAL ;

Carr, JA ;

Mendel, DB ;

Tai, CY ;

Lambkin, R ;

Kelly, L ;

Oxford, JS ;

Hayden, FG ;

Roberts, NA .

ANTIVIRAL RESEARCH, 2002, 55 (02) :307-317

[7] Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008 [J].

Sheu, Tiffany G. ;

Deyde, Varough M. ;

Okomo-Adhiambo, Margaret ;

Garten, Rebecca J. ;

Xu, Xiyan ;

Bright, Rick A. ;

Butler, Ebonee N. ;

Wallis, Teresa R. ;

Klimov, Alexander I. ;

Gubareva, Larisa V. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (09) :3284-3292

[8] The Evolution of Influenza Resistance and Treatment [J].

Weinstock, David M. ;

Zuccotti, Gianna .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 301 (10) :1066-1069

← 1 →