Non-invasive evaluation of liver fibrosis in hepatitis C

被引:7
作者
de Ledinghen, V. [1 ,2 ]
Poynard, T. [3 ,4 ]
Wartelle, C. [5 ]
Rosenthal, E. [6 ]
机构
[1] Hop Haut Leveque, Serv Hepatogastroenterol, Ctr Invest Fibrose Hepat, CHU Bordeaux, F-33604 Pessac, France
[2] Univ Victor Segalen, INSERM, U889, F-33000 Bordeaux, France
[3] Grp Hosp Pitie Salpetriere, Serv Hepatol, F-75013 Paris, France
[4] Univ Paris 06, CNRS, ESA 8067, F-75651 Paris 13, France
[5] Ctr Hosp Pays Aix, Serv Hepatogastroenterol, F-13100 Aix En Provence, France
[6] Hop Archet, Serv Med Interne, F-06200 Nice, France
来源
GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE | 2008年 / 32卷 / 03期
关键词
liver fibrosis; cirrhosis; Fibroscan; hepatitis C; FibroTest;
D O I
10.1016/S0399-8320(08)73271-8
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
In 2007, the "Haute Autorite de Sante" recommended FibroScan, FibroTest or liver biopsy for the initial diagnosis of fibrosis in patients with hepatitis C without co morbidities. These methods have to be interpreted according to the clinical situation, keeping in mind negative and positive false results. For FibroTest, hemolysis, Gilbert syndrome or acute inflammation can modify the result. Pre-analytical and analytical conditions of FibroTest have to be respected according to manufactory recommendations. For FibroScan, the numbers of measurements, the rate of successful measurements, and the interquartile range have to be correct. In case of suspicious results, FibroTest or FibroScan have to be done again. The liver biopsy, FibroTest, and FibroScan are less relevant for the distinction of two adjacent stages of fibrosis. However, their performances are excellent for the diagnosis of severe fibrosis or cirrhosis compared to moderate fibrosis. (C) 2008 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:S90 / S95
页数:6
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