Expression of glucagon-like peptide-1 in the taste buds of rat circumvallate papillae

被引：36

作者：

Feng, Xiao-Hong ^{[1
]}

Liu, Xiao-Min ^{[1
]}

Zhou, Li-Hong ^{[1
]}

Wang, Jing ^{[1
]}

Liu, Guo-Dong ^{[1
]}

机构：

[1] Harbin Med Univ, Clin Hosp 1, Dept Endocrinol, Harbin 150001, Peoples R China

来源：

ACTA HISTOCHEMICA | 2008年 / 110卷 / 02期

关键词：

glucagon-like peptide-1; circumvallate papillae; taste buds; secretion; rat;

D O I：

10.1016/j.acthis.2007.10.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glucagon-like peptide-1 (GLP-1), a 30-amino-acid peptide hormone, is a typical peptide of the brain-gut axis and can affect the metabolism of various tissues and organs. GLP-1 is secreted by intestinal L cells in response to nutrient ingestion. Some studies have shown that taste signaling elements were co-expressed in enteroendocrine cells of the small intestine, and in particular by L-cells. The present study was performed to explore the protein and mRNA expression of GLP-1 in the taste buds of rat circumvallate papillae and to try to determine the significance of its secretion. GLP-1 immunoreactivity was observed in spindle-shaped taste bud cells, with positive cells displaying a characteristic distribution of reaction product that was confined to the cytosol. Reverse transcription polymerase chain reaction (RT-PCR) assay showed that GLP-1 mRNA was expressed in circumvallate papillae. The expression of GLP-1 suggests that it may play an important role in the taste stimulation of nutrients and gut hormone secretion. (C) 2007 Elsevier GmbH. All rights reserved.

引用

页码：151 / 154

页数：4

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