Neurotransmitters as early signals for central nervous system development

被引:304
作者
Nguyen, L
Rigo, JM
Rocher, V
Belachew, S
Malgrange, B
Rogister, B
Leprince, P
Moonen, G
机构
[1] Univ Liege, Ctr Cellular & Mol Neurobiol, B-4020 Liege, Belgium
[2] Univ Liege, CHU Sart Tilman B35, Dept Neurol, B-4000 Liege, Belgium
关键词
ligand-gated ion channels; neural progenitors; neurotransmitters; proliferation; migration; differentiation; survival;
D O I
10.1007/s004410000343
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
During brain ontogenesis, the temporal and spatial generation of the different types of neuronal and glial cells from precursors occurs as a sequence of successive progenitor stages whose proliferation, survival and cell-fate choice are controlled by environmental and cellular regulatory molecules. Neurotransmitters belong to the chemical microenvironment of neural cells, even at the earliest stages of brain development. It is now established that specific neurotransmitter receptors are present on progenitor cells of the developing central nervous system and could play, during neural development, a role that has remained unsuspected until recently. The present review focuses on the occurrence of neurotransmitters and their corresponding ligand-gated ion channel receptors in immature cells, including neural stem cells of specific embryonic and neonatal brain regions. We summarize in vitro and in vivo data arguing that neurotransmitters could regulate morphogenetic events such as proliferation, growth, migration, differentiation and survival of neural precursor cells. The understanding of neurotransmitter function during, early neural maturation could lead to the development of pharmacological tools aimed at improving adult brain repair strategies.
引用
收藏
页码:187 / 202
页数:16
相关论文
共 224 条
[1]   SUBCELLULAR DISTRIBUTION OF TAURINE AND CYSTEINESULPHINATE DECARBOXYLASE IN DEVELOPING RAT BRAIN [J].
AGRAWAL, HC ;
DAVISON, AN ;
KACZMARE.LK .
BIOCHEMICAL JOURNAL, 1971, 122 (05) :759-&
[2]   NICOTINE-INDUCED PROTECTION OF CULTURED CORTICAL-NEURONS AGAINST N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED GLUTAMATE CYTOTOXICITY [J].
AKAIKE, A ;
TAMURA, Y ;
YOKOTA, T ;
SHIMOHAMA, S ;
KIMURA, J .
BRAIN RESEARCH, 1994, 644 (02) :181-187
[4]   AUTORADIOGRAPHIC AND HISTOLOGICAL EVIDENCE OF POSTNATAL HIPPOCAMPAL NEUROGENESIS IN RATS [J].
ALTMAN, J ;
DAS, GD .
JOURNAL OF COMPARATIVE NEUROLOGY, 1965, 124 (03) :319-&
[5]   Activation of the GABA(A) receptor inhibits the proliferative effects of bFGF in cortical progenitor cells [J].
Antonopoulos, J ;
Pappas, IS ;
Parnavelas, JG .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (02) :291-298
[6]   A COMPARISON OF CONCENTRATION OF GLYCINE A TRANSMITTER SUSPECT IN DIFFERENT AREAS OF BRAIN AND SPINAL CORD IN 7 DIFFERENT VERTEBRATES [J].
APRISON, MH ;
SHANK, RP ;
DAVIDOFF, RA .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, 1969, 28 (03) :1345-&
[7]  
Aramakis VB, 1998, J NEUROSCI, V18, P8485
[8]   LOW-DOSES OF L-MONOSODIUM GLUTAMATE PROMOTE NEURONAL GROWTH AND DIFFERENTIATION INVITRO [J].
ARUFFO, C ;
FERSZT, R ;
HILDEBRANDT, AG ;
CERVOSNAVARRO, J .
DEVELOPMENTAL NEUROSCIENCE, 1987, 9 (04) :228-239
[9]   N-METHYL-D-ASPARTATE RECEPTORS ARE CRITICAL FOR MEDIATING THE EFFECTS OF GLUTAMATE ON INTRACELLULAR CALCIUM-CONCENTRATION AND IMMEDIATE-EARLY GENE-EXPRESSION IN CULTURED HIPPOCAMPAL-NEURONS [J].
BADING, H ;
SEGAL, MM ;
SUCHER, NJ ;
DUDEK, H ;
LIPTON, SA ;
GREENBERG, ME .
NEUROSCIENCE, 1995, 64 (03) :653-664
[10]   STIMULATION OF THE N-METHYL-D-ASPARTATE RECEPTOR HAS A TROPHIC EFFECT ON DIFFERENTIATING CEREBELLAR GRANULE CELLS [J].
BALAZS, R ;
HACK, N ;
JORGENSEN, OS .
NEUROSCIENCE LETTERS, 1988, 87 (1-2) :80-86