Mutual effect of cerebral amyloid and peripheral lymphocytes in cognitively normal older individuals

被引:13
作者
Yasuno, Fumihiko [1 ,2 ]
Kazui, Hiroaki [3 ]
Kajimoto, Katsufumi [4 ]
Ihara, Masafumi [4 ]
Morita, Naomi [5 ]
Taguchi, Akihiko [4 ,6 ]
Yamamoto, Akihide [2 ]
Matsuoka, Kiwamu [1 ]
Takahashi, Masato [1 ]
Nakagawara, Jyoji [5 ]
Tsuji, Masahito [7 ]
Iida, Hidehiro [2 ]
Kishimoto, Toshifumi [1 ]
Nagatsuka, Kazuyuki [4 ]
机构
[1] Nara Med Univ, Dept Psychiat, Kashihara, Nara, Japan
[2] Natl Cerebral & Cardiovasc Ctr, Dept Invest Radiol, Suita, Osaka, Japan
[3] Osaka Univ, Dept Neuropsychiat, Sch Med, Suita, Osaka, Japan
[4] Natl Cerebral & Cardiovasc Ctr, Dept Neurol, Suita, Osaka, Japan
[5] Natl Cerebral & Cardiovasc Ctr, Dept Radiol, Suita, Osaka, Japan
[6] Inst Biomed Res & Innovat, Dept Regenerat Med Res, Kobe, Hyogo, Japan
[7] Natl Cerebral & Cardiovasc Ctr, Dept Regenerat Med & Tissue Engn, Suita, Osaka, Japan
基金
日本学术振兴会;
关键词
Alzheimer's disease (AD); amyloid (A); positron emission tomography (PET); C-11-labeled Pittsburgh compound B ([C-11]PiB); CD8 T cells; lymphocytes; POSITRON-EMISSION-TOMOGRAPHY; CENTRAL-NERVOUS-SYSTEM; ALZHEIMERS-DISEASE; T-CELLS; BENZODIAZEPINE-RECEPTOR; IMMUNE SURVEILLANCE; CEREBROSPINAL-FLUID; INCREASED BINDING; HUMAN BRAIN; BLOOD;
D O I
10.1002/gps.4660
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
ObjectiveWe hypothesized that cerebral amyloid accumulation is reflected in the periphery in the pre-dementia stage and used flow cytometry to investigate the peripheral lymphocytes as an easily accessible biomarker to observe neuro-inflammation. We aimed to determine whether peripheral lymphocytes are related to the cortical amyloid burden or vice versa in cognitively normal older subjects. MethodsWe applied [C-11] Pittsburgh compound B (PiB)-positron emission tomography to 36 cognitively normal older individuals, and A deposition was quantified by cortical binding potential (PiB-BPND). Blood samples were obtained, and lymphocyte subsets were evaluated. We examined differences between low and high PiB-BPND groups in the percentage of B cells, T cells, helper T cells, cytotoxic T cells, regulatory T cells, and natural killer cells(.) ResultsSubjects with high PiB-BPND showed significantly higher percentage of cytotoxic T cells (%CD3(+)). Correlation analysis revealed a significant relationship between the percentage of cytotoxic T cells and global cortical mean PiB-BPND. Hierarchical regression analyses showed that cytotoxic T cells were significantly related to the value of global cortical mean PiB-BPND and vice versa. ConclusionsOur results indicated that a specific peripheral immune response, reflected in the increased ratio of cytotoxic T cells, could be regarded as a preclinical sign of AD and could be attributed to the A neuropathological mechanism. Copyright (c) 2017 John Wiley & Sons, Ltd.
引用
收藏
页码:E93 / E99
页数:7
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