Enteropathogenic Escherichia coli type III effectors EspG and EspG2 disrupt the microtubule network of intestinal epithelial cells

被引：54

作者：

Shaw, RK

Smollett, K

Cleary, J

Garmendia, J

Straatman-Iwanowska, A

Frankel, G

Knutton, S

机构：

[1] Univ Birmingham, Inst Child Hlth, Birmingham B4 6NH, W Midlands, England

[2] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, Dept Biol Sci, London SW7 2AZ, England

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.73.7.4385-4390.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Enteropathogenic Escherichia coli infection of intestinal epithelial cells leads to localized depletion of the microtubule cytoskeleton, an effect that is dependent on delivery of type III translocated effector proteins EspG and Orf3 (designated EspG2) to the site of depletion. Microtubule depletion involved disruption rather than displacement of microtubules.

引用

收藏

页码：4385 / 4390

页数：6

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