The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic

被引：212

作者：

Worobey, Michael ^{[1
]}

Levy, Joshua, I ^{[2
]}

Serrano, Lorena Malpica ^{[1
]}

Crits-Christoph, Alexander ^{[3
]}

Pekar, Jonathan E. ^{[4
,5
]}

Goldstein, Stephen A. ^{[6
]}

Rasmussen, Angela L. ^{[7
,8
]}

Kraemer, Moritz U. G. ^{[9
]}

Newman, Chris ^{[10
]}

Koopmans, Marion P. G. ^{[11
,12
]}

Suchard, Marc A. ^{[13
,14
,15
]}

Wertheim, Joel O. ^{[16
]}

Lemey, Philippe ^{[17
,18
]}

Robertson, David L. ^{[19
]}

Garry, Robert F. ^{[18
,20
,21
]}

Holmes, Edward C. ^{[22
,23
]}

Rambaut, Andrew ^{[24
]}

Andersen, Kristian G. ^{[2
,25
]}

机构：

[1] Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA

[2] Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[4] Univ Calif San Diego, Bioinformat & Syst Biol Grad Program, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Dept Biomed Informat, La Jolla, CA 92093 USA

[6] Univ Utah, Dept Human Genet, Sch Med, Salt Lake City, UT 84112 USA

[7] Univ Saskatchewan, Vaccine & Infect Dis Org, Saskatoon, SK S7N 5E3, Canada

[8] Georgetown Univ, Ctr Global Hlth Sci & Secur, Washington, DC 20057 USA

[9] Univ Oxford, Dept Zool, Oxford OX1 3SZ, England

[10] Univ Oxford, Recanati Kaplan Ctr, Dept Zool, Wildlife Conservat Res Unit, Oxford OX13 5QL, England

[11] Erasmus MC, Pandem & Disaster Preparedness Ctr, NL-3015 CE Rotterdam, Netherlands

[12] Erasmus MC, Dept Virosci, NL-3015 CE Rotterdam, Netherlands

[13] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90095 USA

[14] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

[15] Univ Calif Los Angeles, David Geffen Sch Med, Dept Computat Med, Los Angeles, CA 90095 USA

[16] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[17] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Rega Inst Med Res, B-3000 Leuven, Belgium

[18] Global Virus Network GVN, Baltimore, MD 21201 USA

[19] Univ Glasgow, Ctr Virus Res, MRC, Glasgow G61 1QH, Lanark, Scotland

[20] Tulane Univ, Sch Med, Dept Microbiol & Immunol, New Orleans, LA 70112 USA

[21] Zalgen Labs, Frederick, MD 21703 USA

[22] Univ Sydney, Sch Life & Environm Sci, Sydney Inst Infect Dis, Sydney, NSW 2006, Australia

[23] Univ Sydney, Sch Med Sci, Sydney, NSW 2006, Australia

[24] Univ Edinburgh, Inst Evolutionary Biol, Edinburgh EH9 3FL, Midlothian, Scotland

[25] Scripps Res Translat Inst, La Jolla, CA 92037 USA

来源：

SCIENCE | 2022年 / 377卷 / 6609期

基金：

英国惠康基金; 英国医学研究理事会; 加拿大创新基金会; 欧洲研究理事会; 美国国家卫生研究院; 加拿大健康研究院; 澳大利亚研究理事会;

关键词：

SARS-COV-2; TRANSMISSION; HUMANS;

D O I：

10.1126/science.abp8715

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 is critical to preventing future zoonotic outbreaks before they become the next pandemic. The Huanan Seafood Wholesale Market in Wuhan, China, was identified as a likely source of cases in early reports, but later this conclusion became controversial. We show here that the earliest known COVID-19 cases from December 2019, including those without reported direct links, were geographically centered on this market. We report that live SARS-CoV-2-susceptible mammals were sold at the market in late 2019 and that within the market, SARS-CoV-2-positive environmental samples were spatially associated with vendors selling live mammals. Although there is insufficient evidence to define upstream events, and exact circumstances remain obscure, our analyses indicate that the emergence of SARS-CoV-2 occurred through the live wildlife trade in China and show that the Huanan market was the epicenter of the COVID-19 pandemic.

引用

页码：951 / 959

页数：9

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