Incidence of fatal adverse drug reactions:: a population based study

被引:206
作者
Wester, Karin [1 ]
Jonsson, Anna K. [1 ]
Spigset, Olav [2 ,3 ]
Druid, Henrik [4 ]
Hagg, Staffan [1 ]
机构
[1] Linkoping Univ, Div Clin Pharmacol, SE-58185 Linkoping, Sweden
[2] St Olavs Univ Hosp, Div Clin Pharmacol, NO-7006 Trondheim, Norway
[3] Norwegian Univ Sci & Technol, Dept Lab Med Childrens & Womens Hlth, NO-7006 Trondheim, Norway
[4] Karolinska Inst, Dept Forens Med, SE-17177 Stockholm, Sweden
关键词
adverse drug reactions; epidemiology; mortality; population based study;
D O I
10.1111/j.1365-2125.2007.03064.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
AIMS To determine the incidence of fatal adverse drug reactions (FADRs) in a Swedish population. METHODS Every seventh randomly selected deceased in three counties in South-east Sweden during 1 January 2001-31 December 2001 was identified in the Cause of Death Register. Relevant case records (hospitals and/or primary care centres and medicolegal files) were reviewed to identify suspected drug-related fatalities. RESULTS Of 1574 deceased study subjects, 49 (3.1%; 95% CI 2.2%, 4.0%) were suspected to have died from FADRs. The most common suspected FADRs were gastrointestinal haemorrhages (n = 18; 37%), central nervous system haemorrhages (n = 14; 29%), cardiovascular disorders (n = 5; 10%), other haemorrhages (n = 4; 8%) and renal dysfunction (n = 3; 6%). The drugs most commonly implicated in FADRs were antithrombotic drugs (n = 31; 63%), followed by nonsteroidal anti-inflammatory drugs (NSAIDs) (n = 9; 18%), antidepressants (n = 7; 14%) and cardiovascular drugs (n = 4; 8%). Of all the 639 fatalities in hospital 41 (6.4%; 95% CI 4.5%, 8.3%) were suspected to be due to FADRs. CONCLUSIONS The medical burden of FADRs is significant. Haemorrhages were seen in a majority of the FADRs; antithrombotic agents or NSAIDs were implicated in most of these events. These results suggest that preventive measures should be taken to reduce the number of deaths caused by drugs.
引用
收藏
页码:573 / 579
页数:7
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