The prognostic significance of tumor angiogenesis in Taiwanese patients with invasive ductal breast carcinomas

被引：8

作者：

Chu, JS

Huang, CS

Chang, KJ

机构：

[1] Natl Taiwan Univ Hosp, Dept Pathol, Taipei 100, Taiwan

[2] Natl Taiwan Univ, Coll Med, Dept Surg, Taipei 10018, Taiwan

来源：

CANCER LETTERS | 1998年 / 134卷 / 01期

关键词：

angiogenesis; breast cancer; microvessel count; prognosis;

D O I：

10.1016/S0304-3835(98)00231-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiogenesis plays an important role in tumor growth and metastasis. We performed an immunohistochemical study by anti-CD31 antibody to investigate the prognostic significance of microvessel count (MVC) in 163 Taiwanese patients with primary invasive ductal breast carcinomas. Univariate analysis revealed that MVC per 200x field correlated significantly with disease-free (P < 0.001) and overall survival (P < 0.0008). In 74 patients with node-negative tumors, MVC also significantly correlated with disease-free (P < 0.03) and overall survival (P < 0.007). Multivariate Cox regression analysis demonstrated that MVC is an independent factor in predicting disease-free (P < 0.02) and overall survival (P < 0.02). Our study confirms that tumor angiogenesis as measured by MVC is a reliable independent prognostic factor of breast cancer. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：7 / 14

页数：8

共 25 条

[1] PROGNOSTIC VALUE OF INTRATUMORAL MICROVESSEL DENSITY, A MEASURE OF TUMOR ANGIOGENESIS, IN NODE-NEGATIVE BREAST-CARCINOMA - RESULTS OF A MULTIPARAMETRIC STUDY [J].