Synthesis and cytotoxicity of novel sansalvamide A derivatives

被引：38

作者：

Carroll, CL

Johnston, JVC

Kekec, A

Brown, JD

Parry, E

Cajica, J

Medina, I

Cook, KM

Corral, R

Pan, PS

McAlpine, SR

机构：

[1] San Diego State Univ, Dept Chem, Inst Mol Biol, San Diego, CA 92182 USA

[2] San Diego State Univ, Ctr Appl & Expt Genom, San Diego, CA 92182 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 16期

关键词：

D O I：

10.1021/ol051161g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Described are the syntheses of 14 derivatives of the natural product Sansalvamide A, where two are more active against HCT 116 colon cancer cell lines than the natural product. These derivatives were synthesized using a combinatorial-type strategy that permits elucidation of the amino acid role in the cytotoxicity, and they lay the groundwork for development of new anticancer agents.

引用

页码：3481 / 3484

页数：4

共 50 条

[21] Synthesis, cytotoxicity and computational study of novel protoberberine derivatives
Simic, Milena R.
Damjanovic, Ana B.
Kalinic, Marko D.
Tasic, Gordana D.
Eric, Slavica M.
Antic-Stankovic, Jelena A.
Savic, Vladimir M.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2016, 81 (02) : 103 - 123
[22] SYNTHESIS AND CYTOTOXICITY OF NOVEL THIOPHENE, PYRAN AND PYRIDINE DERIVATIVES
Wardakhan, Wagnat W.
Samir, Eman M.
El-Arab, Elham E.
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, 2018, 32 (02) : 259 - 270
[23] Novel Adamantane Derivatives: Synthesis, Cytotoxicity and Antimicrobial Properties
Popiolek, Lukasz
Janas, Wiktoria
Hordyjewska, Anna
Biernasiuk, Anna
APPLIED SCIENCES-BASEL, 2024, 14 (09):
[24] Synthesis and in vitro cytotoxicity evaluation of novel naphthindolizinedione derivatives
Defant, Andrea
Guella, Graziano
Mancini, Ines
ARCHIV DER PHARMAZIE, 2007, 340 (03) : 147 - 153
[25] Synthesis and Tumor Cytotoxicity of Novel Amide Derivatives of β-Hederin
Liu, Yang
Lu, Wen-Xiang
Yan, Mao-Cai
Yu, Yang
Ikejima, Takashi
Cheng, Mao-Sheng
MOLECULES, 2010, 15 (11): : 7871 - 7883
[26] Synthesis, antimicrobial activity and cytotoxicity of novel oxadiazole derivatives
Kaplancikli, Zafer Asim
Altintop, Mehlika Dilek
Turan-Zitouni, Gulhan
Ozdemir, Ahmet
Ozic, Rasime
Akalin, Gulsen
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2012, 27 (01) : 51 - 57
[27] Synthesis and Anticholinesterase Activity and Cytotoxicity of Novel Amide Derivatives
Altintop, Mehlika Dilek
Kaplancikli, Zafer Asim
Ozdemir, Ahmet
Turan-Zitouni, Gulhan
Temel, Halide Edip
Akalin, Gulsen
ARCHIV DER PHARMAZIE, 2012, 345 (02) : 112 - 116
[28] MEDI 166-Synthesis and potency of Sansalvamide A derivatives in pancreatic cancers
Ravula, Suchitra
Pan, Po-Shen
Styers, Thomas J.
Rodriguez, Rodrigo
Parry, Emily
Brown, Joseph D.
Singh, Erin
Pan, Chung-Mao
McGuire, Kathleen L.
McAlpine, Shelli R.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
[29] Synthesis of sansalvamide A derivates
Brown, JD
Kekec, A
McAlpine, S
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U2593 - U2594
[30] Synthesis of novel, azasugar-modified anthraquinone derivatives and their cytotoxicity
Zhang, Ping-Zhu
Yang, Hai-Long
Li, Cui-Cui
Xia, Zhi-Chao
Wang, Xiao-Man
Wei, Hua
Rong, Rui-Xue
Cao, Zhi-Ran
Wang, Ke-Rang
Chen, Hua
Li, Xiao-Liu
CHINESE CHEMICAL LETTERS, 2014, 25 (07) : 1057 - 1059

← 1 2 3 4 5 →