Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics

被引：137

作者：

Li, Chun-yang ^{[2
,3
]}

Wang, En-qin ^{[2
,3
]}

Cheng, Yan ^{[1
]}

Bao, Jin-ku ^{[2
,3
]}

机构：

[1] Penn State Univ, Dept Pharmacol, Hershey, PA 17033 USA

[2] Sichuan Univ, Sch Life Sci, Chengdu 610064, Peoples R China

[3] Sichuan Univ, State Key Lab Oral Dis, Chengdu 610064, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2011年 / 43卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Oridonin; Cell cycle arrest; Apoptosis; Autophagy; Anti-neoplastic drug; FIBROSARCOMA L929 CELLS; SIGNAL-REGULATED KINASE; CYTOCHROME-C RELEASE; IN-VITRO; RABDOSIA-RUBESCENS; ANTITUMOR-ACTIVITY; KAPPA-B; ACTIVATION; MCF-7; VIVO;

D O I：

10.1016/j.biocel.2011.01.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is well-known that cell cycle arrest and/or death play a pivotal role in tumor progression, which has drawn a rising attention for cancer biologists due to their complex and intricate relationships. In this review, we demonstrate the recent research on oridonin, an active diterpenoid with remarkable anti-proliferative activities, and then further explore its molecular mechanisms of cell cycle arrest, apoptosis, autophagy and their cross-talks in various cancer cells, which may provide a new perspective of oridonin as a candidate anti-neoplastic drug for future cancer therapeutics. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：701 / 704

页数：4

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