Plaque-neutralizing antibody to BA.2.12.1, BA.4 and BA.5 in individuals with three doses of BioNTech or CoronaVac vaccines, natural infection and breakthrough infection

被引：21

作者：

Cheng, Samuel S. M. ^{[1
]}

Mok, Chris K. P. ^{[2
,3
]}

Li, John K. C. ^{[1
]}

Ng, Susanna S. ^{[4
]}

Lam, Bosco H. S. ^{[5
]}

Jeevan, Trushar ^{[6
]}

Kandeil, Ahmed ^{[6
]}

Pekosz, Andrew ^{[7
]}

Chan, Karl C. K. ^{[1
]}

Tsang, Leo C. H. ^{[1
]}

Ko, Fanny W. ^{[4
]}

Chen, Chunke ^{[2
,3
]}

Yiu, Karen ^{[4
]}

Luk, Leo L. H. ^{[1
]}

Chan, Ken K. P. ^{[4
]}

Webby, Richard J. ^{[6
]}

Poon, Leo L. M. ^{[1
]}

Hui, David S. C. ^{[4
,8
]}

Peiris, Malik ^{[1
,9
]}

机构：

[1] Univ Hong Kong, LKS Fac Med, Sch Publ Hlth, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Fac Med, Hong Kong, Peoples R China

[4] Chinese Univ Hong Kong, Fac Med, Dept Med & Therapeut, Hong Kong, Peoples R China

[5] North Lantau Hosp, Dept Pathol, Hong Kong, Peoples R China

[6] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN USA

[7] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD USA

[8] Chinese Univ Hong Kong, Fac Med, Stanley Ho Ctr Emerging Infect Dis, Hong Kong, Peoples R China

[9] Ctr Immunol & Infect, Shatin, Hong Kong Sci Pk, Hong Kong, Peoples R China

来源：

JOURNAL OF CLINICAL VIROLOGY | 2022年 / 156卷

基金：

中国国家自然科学基金;

关键词：

COVID-19; SARS-CoV-2; Omicron; Neutralization; Vaccine;

D O I：

10.1016/j.jcv.2022.105273

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: BA.2.12.1, BA.4 and BA.5 subvariants of SARS-CoV-2 variant-of-concern (VOC) Omicron (B.1.1.529) are spreading globally. They demonstrate higher transmissibility and immune escape. Objectives: Determine BA.2.12.1, BA.4 and BA.5 virus plaque reduction neutralization test (PRNT) antibody titres in individuals recently vaccinated with BNT162b2 (n = 20) or CoronaVac (n = 20) vaccines or those convalescent from ancestral wild-type (WT) SARS-CoV-2 (n = 20) or BA.2 infections with (n = 17) or without (n = 7) prior vaccination. Results: Relative to neutralization of the WT virus, those vaccinated with BNT162b2 had 4.8, 3.4, 4.6, 11.3 and 15.5-fold reductions of geometric mean antibody titres (GMT) to BA.1, BA.2, BA.2.12.1, BA.4 and BA.5 viruses, respectively. Similarly, those vaccinated with CoronaVac had 8.0, 7.0, 11.8, 12.0 and 12.0 fold GMT reductions and those with two doses of CoronaVac boosted by BNT162b2 had 6.1, 6.7, 6,3, 13.0 and 21.2 fold GMT reductions to these viruses, respectively. Vaccinated individuals with BA.2 breakthrough infections had higher GMT antibody levels vs. BA.4 (36.9) and BA.5 (36.9) than unvaccinated individuals with BA.2 infections (BA.4 GMT 8.2; BA.5 GMT 11.0). Conclusions: BA.4 and BA.5 subvariants were less susceptible to BNT162b2 or CoronaVac vaccine elicited antibody neutralization than subvariants BA.1, BA.2 and BA.2.12.1. Nevertheless, three doses BNT162b2 or booster of BNT162b2 following two doses of CoronaVac elicited detectable BA.4 and BA.5 neutralizing antibody responses while those vaccinated with three doses of CoronaVac largely fail to do so. BA.2 infections in vaccinated individuals led to higher levels of BA.4 or BA.5 neutralizing antibody compared to those who were vaccine-naive.

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