A facile access to condensed and spirosubstituted pyrimidine phosphor esters

被引：18
作者：
Abdou, Wafaa M. [1 ]
Salem, Mounir A. I. [2 ]
Barghasha, Reham F. [1 ]
机构：
[1] Natl Res Ctr, Chem Ind Div, Cairo 12622, Egypt
[2] Ain Shams Univ, Fac Sci, Dept Chem, Cairo, Egypt
来源：
ARKIVOC | 2007年
关键词：
alloxan-5-oximes; substituted bis-heterocycle phosphor esters; Wittig-Horner carbanions; pyrimidines; anti-tumor activity; structure-activity relationship (SAR);
D O I：
10.3998/ark.5550190.0008.f06
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of alloxan-5-oximes with different types of phosphonate carbanions gave moderate to high yields of condensed and spiro bis-heterocyclic systems bearing a phosphonate substituent. Mechanisms for the formation of the five- and six-membered rings were provided. A marked resemblance between alloxan-5-oxime and 1,3-dimethyl derivative is observed through the studied reactions. The bioassay indicated that some of the products have good selective antitumor activity and the structure-activity relationship (SAR) of new phosphonates has also been studied.
引用
收藏
页码：45 / 60
页数：16
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