A facile access to condensed and spirosubstituted pyrimidine phosphor esters

被引：18

作者：

Abdou, Wafaa M. ^{[1
]}

Salem, Mounir A. I. ^{[2
]}

Barghasha, Reham F. ^{[1
]}

机构：

[1] Natl Res Ctr, Chem Ind Div, Cairo 12622, Egypt

[2] Ain Shams Univ, Fac Sci, Dept Chem, Cairo, Egypt

来源：

ARKIVOC | 2007年

关键词：

alloxan-5-oximes; substituted bis-heterocycle phosphor esters; Wittig-Horner carbanions; pyrimidines; anti-tumor activity; structure-activity relationship (SAR);

D O I：

10.3998/ark.5550190.0008.f06

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of alloxan-5-oximes with different types of phosphonate carbanions gave moderate to high yields of condensed and spiro bis-heterocyclic systems bearing a phosphonate substituent. Mechanisms for the formation of the five- and six-membered rings were provided. A marked resemblance between alloxan-5-oxime and 1,3-dimethyl derivative is observed through the studied reactions. The bioassay indicated that some of the products have good selective antitumor activity and the structure-activity relationship (SAR) of new phosphonates has also been studied.

引用

页码：45 / 60

页数：16

共 28 条

[1] Synthesis of spiro and fused five membered N-heterocycles from alkylidenephosphoranes [J].