Dorothy Hodgkin Lecture 2010 From hype to hope? A journey through the genetics of Type 2 diabetes

被引：10
作者：
McCarthy, M. I. [1 ,2 ]
机构：
[1] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Wellcome Trust Ctr Human Genet, Oxford OX3 7LJ, England
[2] Churchill Hosp, Oxford NIHR Biomed Res Ctr, Oxford OX3 7LJ, England
来源：
DIABETIC MEDICINE | 2011年 / 28卷 / 02期
基金：
英国惠康基金; 英国医学研究理事会; 美国国家卫生研究院;
关键词：
association; genetics; genome-wide association studies; physiology; Type; 2; diabetes; GENOME-WIDE ASSOCIATION; LARGE-SCALE ASSOCIATION; BIRTH-WEIGHT; SUSCEPTIBILITY LOCI; INSULIN-RESISTANCE; COMPLEX DISEASES; COMMON VARIANT; GLUCOSE-LEVELS; FTO GENE; RISK;
D O I：
10.1111/j.1464-5491.2010.03194.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
P>Recent advances in genetic analysis have enabled researchers to perform genome-wide surveys for common DNA sequence variants associated with risk of Type 2 diabetes and related traits. Over the past 4 years, these endeavours have extended the number of proven Type 2 diabetes-susceptibility loci from a handful to the current total of over 40. Each of these loci provides an opportunity to uncover insights into the biology of glucose regulation and the pathogenesis of Type 2 diabetes, insights which should support clinical translation to identify novel ways of treating and preventing disease. Here, I describe (i) progress in identification of diabetes-susceptibility loci; (ii) biological insights that have been gained in the relatively short period since these loci were discovered; and (iii) the challenges that need to be addressed if we are to maximize the translational benefits of this research.
引用
收藏
页码：132 / 140
页数：9
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