Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiation

被引：190

作者：

Noel, Timothy ^{[2
]}

Naber, John R. ^{[2
]}

Hartman, Ryan L. ^{[1
]}

McMullen, Jonathan P. ^{[1
]}

Jensen, Klavs F. ^{[1
]}

Buchwald, Stephen L. ^{[2
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

CHEMICAL SCIENCE | 2011年 / 2卷 / 02期

关键词：

CROSS-COUPLING REACTIONS; ARYL CHLORIDES; MICROREACTOR; PRECATALYSTS; INDUSTRIES; ARYLAMINES; OXIDATION; BROMIDES; HALIDES; REACTOR;

D O I：

10.1039/c0sc00524j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A continuous-flow palladium-catalyzed amination reaction was made possible through efficient handling of solids via acoustic irradiation. Various diarylamines were obtained with reaction times ranging from 20 s to 10 min.

引用

页码：287 / 290

页数：4

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