In vitro and intracellular activities of LBM415 (NVP PDF-713) against Legionella pneumophila

被引：7

作者：

Edelstein, PH

Hu, BF

Edelstein, MAC

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 06期

关键词：

D O I：

10.1128/AAC.49.6.2533-2535.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

LBM415 activity against extracellular and intracellular Legionella pneumophila was studied. The LBM415 MIC,, for 20 Legionella sp. strains was 4 μ g/ml, versus 0.06, 0.25, and ≤ 0.03 μ g/ml for azithromycin, erythromycin, and levofloxacin, respectively. LBM415 (0.5 and 16 μ g/ml) reversibly prevented intracellular growth of two L. pneumophila strains and was less active than erythromycin.

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页码：2533 / 2535

页数：3

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