Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora

被引：27
作者：
Rathnayake, G. R. Nalin [1 ]
Savitri Kumar, N. [1 ]
Jayasinghe, Lalith [1 ]
Araya, Hiroshi [2 ]
Fujimoto, Yoshinori [1 ,2 ]
机构：
[1] Natl Inst Fundamental Studies, Hantana Rd, Kandy, Sri Lanka
[2] Meiji Univ, Sch Agr, Kawasaki, Kanagawa 2148571, Japan
来源：
NATURAL PRODUCTS AND BIOPROSPECTING | 2019年 / 9卷 / 06期
关键词：
Pestalotiopsis microspora; Manilkara zapota; Endophyte; Pitholide E; Pestalotin; DERIVATIVES; PYRONE; OXYSPORONE; ANALOG;
D O I：
10.1007/s13659-019-00225-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition to previously identified pitholide B (2), pitholide D (3), pestalotin (LL-P880 alpha) (4), PC-2 (5), LL-P880 beta (6), tyrosol (7) and 4-oxo-4H-pyran-3-acetic acid (8). An endophytic fungus P. microspora from M. zapota and the isolation of compounds 1-5, 7 and 8 from P. microspora are reported here for the first time. Graphic
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页码：411 / 417
页数：7
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