Overexpression of long non-coding RNA MALAT1 is correlated with clinical progression and unfavorable prognosis in pancreatic cancer

被引:178
作者
Pang, Er-Jun [1 ]
Yang, Rui [2 ]
Fu, Xi-bo [3 ]
Liu, Ye-fu [3 ]
机构
[1] Shanghai Jiao Tong Univ, Dept Surg, Peoples Hosp 6, Shanghai 200233, Peoples R China
[2] Fifth Hosp Wuhan, Dept Gen Surg, Wuhan 430050, Peoples R China
[3] Dalian Med Univ, Clin Oncol Coll, Dept Hepatobiliary Surg, Liaoning Canc Hosp & Inst, Dalian 110042, Liaoning, Peoples R China
关键词
lncRNA; MALAT1; Pancreatic cancer; Prognosis; MIGRATION; METASTASIS; EXPRESSION; DIAGNOSIS; LNCRNA;
D O I
10.1007/s13277-014-2850-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Long non-coding RNAs (lncRNAs) have been proved to serve as a critical role in cancer development and progression. However, little is known about the pathological role of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in pancreatic cancer patients. The aims of this study are to measure the expression of lncRNA MALAT1 in pancreatic cancer patients and to explore the clinical significance of the lncRNA MALAT1. Using qRT-PCR, the expression of lncRNA MALAT1 was measured in 126 pancreatic cancer tissues and 15 adjacent non-cancerous tissues. In the present study, our results indicated that lncRNA MALAT1 was highly expressed in pancreatic cancer compared with adjacent non-cancerous tissues (P<0.001), and positively correlated with clinical stage (early stages vs. advanced stages, P<0.001), tumor size (<2 vs. >= 2 cm, P=0.004), lymph node metastasis (negative vs. positive, P<0.001), and distant metastasis (absent vs. present, P=0.001) in pancreatic cancer patients. Furthermore, we also found that lncRNA MALAT1 overexpression was an unfavorable prognostic factor in pancreatic cancer patients (P<0.001), regardless of clinical stage, tumor size, lymph node metastasis, and distant metastasis. Finally, increased lncRNA MALAT1 expression was an independent poor prognostic factor for pancreatic patients through multivariate analysis (P=0.018). In conclusion, overexpression of lncRNA MALAT1 serves as an unfavorable prognostic biomarker in pancreatic cancer patients.
引用
收藏
页码:2403 / 2407
页数:5
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