Impact of Reactive Oxygen and Nitrogen Species Produced by Plasma on Mdm2-p53 Complex

被引：7
作者：
Attri, Pankaj [1 ,2 ]
Kurita, Hirofumi [3 ]
Koga, Kazunori [4 ,5 ]
Shiratani, Masaharu [1 ,4 ]
机构：
[1] Kyushu Univ, Ctr Plasma Nanointerface Engn, Fukuoka 8190395, Japan
[2] Kyushu Univ, Grad Sch Informat Sci & Elect Engn, Fukuoka 8190395, Japan
[3] Toyohashi Univ Technol, Dept Appl Chem & Life Sci, Toyohashi, Aichi 4418580, Japan
[4] Kyushu Univ, Fac Informat Sci & Elect Engn, Fukuoka 8190395, Japan
[5] Natl Inst Nat Sci, Ctr Novel Sci Initiat, Tokyo 1050001, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 17期
关键词：
Mdm2-p53; plasma treatment; molecular dynamic (MD) simulations; MOLECULAR-DYNAMICS; OXIDATIVE STRESS; P53; PROTEIN; INACTIVATION; RESISTANCE; INHIBITORS; SIMULATIONS; ACTIVATION; CISPLATIN;
D O I：
10.3390/ijms22179585
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The study of protein-protein interactions is of great interest. Several early studies focused on the murine double minute 2 (Mdm2)-tumor suppressor protein p53 interactions. However, the effect of plasma treatment on Mdm2 and p53 is still absent from the literature. This study investigated the structural changes in Mdm2, p53, and the Mdm2-p53 complex before and after possible plasma oxidation through molecular dynamic (MD) simulations. MD calculation revealed that the oxidized Mdm2 bounded or unbounded showed high flexibility that might increase the availability of tumor suppressor protein p53 in plasma-treated cells. This study provides insight into Mdm2 and p53 for a better understanding of plasma oncology.
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页数：14
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